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Clomipramine and exposure for compulsive rituals: II. Plasma levels, side effects and outcome.

Author: LuscombeD K, MarksI M, MawsonD, SternR S

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Clomipramine treatment for obsessive-compulsive disorder was most effective with plasma levels in specific ranges.
Paper Details　
Original Abstract of the Article :
Forty obsessive-compulsive ritualizers received nightly placebo or clomipramine up to 225 mgs nocte for 8 months, and received behavioural treatment (exposure to vivo) from weeks 4 to 10. Plasma concentrations of clomipramine and its primary metabolite N-desmethylclomipramine steadily increased over...See full text at original site
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引用元：
https://doi.org/10.1192/bjp.136.2.161

データ提供：米国国立医学図書館（NLM）

Clomipramine and Exposure for Compulsive Rituals

This research study takes us on a journey into the world of obsessive-compulsive disorder (OCD), exploring the potential benefits of combining clomipramine medication with exposure therapy. The study, like a skilled desert navigator, seeks to map out the most effective path to relief for individuals struggling with OCD, a condition that can feel like a never-ending sandstorm in their lives. The research explores the relationship between clomipramine levels, side effects, and treatment outcomes, seeking to optimize the experience of patients.

Navigating the Desert of Obsessive-Compulsive Disorder

The study found that patients with specific plasma levels of clomipramine and its metabolite showed significant improvement, suggesting a therapeutic window for this medication. This finding is like discovering a hidden oasis in the vast desert of OCD, offering a potential path to relief and well-being.

Finding Comfort in the Sandstorm of OCD

The study highlights the importance of personalized treatment approaches for OCD. Finding the right combination of medication and therapy can help individuals manage their symptoms and find a path to a more peaceful and fulfilling life.

Dr. Camel's Conclusion

The study reminds us that the journey through OCD can be long and challenging, but there is hope for relief and recovery. Combining clomipramine medication with exposure therapy offers a promising path to navigate the sandstorms of OCD and find a more peaceful oasis.

Date :
  1. Date Completed 1980-07-28
  2. Date Revised 2019-07-05
Further Info :

Pubmed ID

7370482

DOI: Digital Object Identifier

10.1192/bjp.136.2.161

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・Side Effects of clomipramine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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