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[Multidimensional psychometric assessment of preoperative mood. Effects of zolpidem compared to phenobarbital combined with promethazine as premedication].

Author: HüppeM, NidermaierB, UhligT

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This double-blind, randomized study compared the effects of zolpidem and phenobarbital on preoperative mood. Zolpidem was found to increase hostility, while promethazine led to deactivation. The study emphasizes the importance of multidimensional rating scales for measuring preoperative mood and suggests that promethazine may be a valuable addition to premedication regimens.
Paper Details　
Original Abstract of the Article :
The following double-blind, randomised study dealt with three questions: (1) Is a multidimensional psychometric rating scale suitable for the measurement of mood before anaesthesia? (2) What are the effects of the new benzodiazepine-like drug zolpidem on preoperative mood compared with phenobarbital...See full text at original site
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引用元：
https://doi.org/10.1007/s001010050199

データ提供：米国国立医学図書館（NLM）

Preoperative Mood: A Multifaceted Puzzle

This research explores the impact of premedication on preoperative mood, adding a new dimension to the field of [anesthesiology]. The study utilizes a multidimensional psychometric rating scale to assess mood before anesthesia, comparing the effects of zolpidem, a benzodiazepine-like drug, to phenobarbital. The authors highlight the importance of considering not only sedative effects but also potential negative mood changes when choosing premedication.

Zolpidem and Phenobarbital: A Tale of Two Sedatives

The research found that zolpidem led to significantly higher expressions of hostility compared to phenobarbital, while promethazine, a common premedication, resulted in greater deactivation (tiredness and numbness). This suggests that the choice of premedication can have significant effects on mood and requires careful consideration based on the patient's individual needs and the potential for negative side effects. Further research is needed to better understand the complex interplay between premedication, mood, and anesthesia.

Choosing the Right Premedication: A Balancing Act

Similar to a camel choosing a path through a desert, the choice of premedication involves a balance of benefits and risks. While zolpidem and phenobarbital can provide sedation, their effects on mood must be carefully considered. The study highlights the importance of a multidimensional approach to assessing mood before anesthesia, which can help clinicians choose the most appropriate premedication for each patient. This research emphasizes the need for personalized care in the realm of premedication.

Dr.Camel's Conclusion

This research provides valuable insights into the complexities of premedication and its impact on preoperative mood. While the study suggests that zolpidem and phenobarbital have distinct effects on mood, further research is needed to understand their individual implications. The importance of a multidimensional assessment of mood underscores the need for personalized care in premedication, ensuring a safe and comfortable experience for patients.

Date :
  1. Date Completed 1995-12-20
  2. Date Revised 2019-10-31
Further Info :

Pubmed ID

7485925

DOI: Digital Object Identifier

10.1007/s001010050199

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・Effects of promethazine
SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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