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A pilot safety and immunogenicity study of the malaria vaccine SPf66 in Gambian infants.

Author: BallouW R, BennettS, D'AlessandroU, DrakeleyC J, FeganG W, GreenwoodB M, LeachA, TargettG A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The malaria vaccine SPf66 produced modest local reactions but no significant systemic side effects in 150 Gambian infants. The Colombian-produced SPf66 was more immunogenic than the US-produced vaccine.
Paper Details　
Original Abstract of the Article :
A pilot safety and immunogenicity trial of the malaria vaccine SPf66 has been undertaken in 150 Gambian infants. No significant systemic side effects were recorded but modest local reactions were seen after the administration of a third 1.0 mg dose. SPf66 produced in Colombia was more immunogenic th...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
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引用元：
https://doi.org/10.1111/j.1365-3024.1995.tb00912.x

データ提供：米国国立医学図書館（NLM）

A Pilot Study of the Malaria Vaccine SPf66 in Gambian Infants

The quest for a safe and effective malaria vaccine is a long and arduous journey. This study reports on a pilot safety and immunogenicity trial of the malaria vaccine SPf66 in Gambian infants. It's like a caravan crossing the desert, testing the effectiveness of a new tool against a formidable enemy. The authors evaluate the safety and immunogenicity of SPf66 and explore its potential to protect young children from malaria.

SPf66: A Promising Malaria Vaccine

The study demonstrates that SPf66 was generally well-tolerated, with minimal side effects. However, the vaccine's immunogenicity was found to be variable, depending on the manufacturing process and the dose administered. It's like a desert oasis, offering a promising source of protection but requiring careful management to maximize its effectiveness.

The Importance of Continued Research

This study emphasizes the need for further research to optimize the production and administration of SPf66 to achieve optimal efficacy. It's like a guidepost in the desert, pointing towards the path of continued research and development to refine this promising malaria vaccine and protect vulnerable populations.

Dr.Camel's Conclusion

This pilot study offers a valuable glimpse into the potential of the malaria vaccine SPf66. It highlights the importance of continued research and development to refine this promising vaccine and ultimately protect vulnerable populations from this devastating disease.

Date :
  1. Date Completed 1996-01-17
  2. Date Revised 2019-09-13
Further Info :

Pubmed ID

7501425

DOI: Digital Object Identifier

10.1111/j.1365-3024.1995.tb00912.x

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Languages

English

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