Paper Details

  1. Home
  2. Paper Details

Vitamin D3, a possible nuclear protector in normal hepatic and medullar tissue in white Wistar rats treated with cytostatics. Radioisotopic and cytogenetic aspects.

Author: ConstantiniuL, CostacheA, GeorgianL, GeormăneanuC, HudităV, LenghelZ, MihalacheD

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Vitamin D3 was found to protect against the harmful effects of cytostatic substances in rats. Vitamin D3 reduced the incorporation of 3H thymidine and restored RNA synthesis to normal levels. This suggests that vitamin D3 protects DNA stability.
Paper Details　
Original Abstract of the Article :
Vitamin D3 was given to male Wistar rats in 3 doses totalling 10,000 IU/kg b.w. then, within 24 hrs, girostan (10 mg/kg b.w.), lomustin or CCNU (10 mg/kg b.w.), all cytostatic substances, were injected in a single dose. Association of vitamin D3 with these cytostatics was found to reduce incorporati...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/7535155

データ提供：米国国立医学図書館（NLM）

Vitamin D3: A Potential Shield Against Cytotoxic Damage

Navigating the complex world of cancer treatment, we seek protective measures to minimize collateral damage. This study investigates the potential of vitamin D3 as a shield against the damaging effects of cytostatics, a class of drugs used in cancer therapy. The authors explored the impact of vitamin D3 on Wistar rats exposed to various cytostatics, analyzing its effects on cellular processes and DNA integrity.

Vitamin D3: A Protective Oasis in the Cytotoxic Desert

The study revealed that vitamin D3 exhibited a protective effect against the detrimental effects of cytostatics. It significantly reduced the incorporation of a DNA building block (3H thymidine), suggesting a stabilizing effect on DNA. Furthermore, the study demonstrated that vitamin D3 reduced DNA damage, as evidenced by a decrease in the number of chromosomal abnormalities. These findings suggest that vitamin D3 could potentially mitigate some of the adverse effects associated with cancer treatments.

Vitamin D3: A Potential Ally in the Battle Against Cancer

While further research is needed, this study offers a glimmer of hope in the vast desert of cancer treatment. It suggests that vitamin D3 could potentially play a role in protecting healthy tissues from the damaging effects of chemotherapy. However, it's crucial to consult with a healthcare professional before making any changes to your diet or supplement regimen, as vitamin D3 dosage should be carefully monitored.

Dr.Camel's Conclusion

Like a camel navigating a scorching desert, we must be vigilant in protecting ourselves from the harmful effects of cancer treatments. This study suggests that vitamin D3 could act as a protective oasis, potentially mitigating the damaging effects of cytostatics. While further research is necessary, this study offers a valuable insight into the potential benefits of vitamin D3 in cancer treatment.

Date :
  1. Date Completed 1995-05-04
  2. Date Revised 2016-10-21
Further Info :

Pubmed ID

7535155

DOI: Digital Object Identifier

7535155

Related Literature

Article Analysis
・Effects of thiotepa injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.