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Initial severity and differential treatment outcome in the National Institute of Mental Health Treatment of Depression Collaborative Research Program.

Author: ElkinI, GibbonsR D, HedekerD, PilkonisP A, SheaM T, SotskyS M, WatkinsJ T

Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Initial severity of depression and impairment of functioning significantly predicted treatment effects for major depressive disorder. Active treatments showed greater differences for more severely ill patients, highlighting the importance of initial severity in treatment success.
Paper Details　
Original Abstract of the Article :
Random regression models (RRMs) were used to investigate the role of initial severity in the outcome of 4 treatments (cognitive-behavior therapy [CBT], interpersonal psychotherapy [IPT], imipramine plus clinical management [IMI-CM], and placebo plus clinical management [PLA-CM]) for outpatients with...See full text at original site
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引用元：
https://doi.org/10.1037//0022-006x.63.5.841

データ提供：米国国立医学図書館（NLM）

The Impact of Initial Severity on Depression Treatment: A Camel's Journey Through the Desert of Mental Health

Depression is a complex mental health condition that can feel like a long and arduous journey through a vast desert. This study explores the role of initial severity in the effectiveness of different treatments for major depressive disorder. The researchers analyzed data from the National Institute of Mental Health Treatment of Depression Collaborative Research Program, comparing the outcomes of four treatments: cognitive-behavior therapy (CBT), interpersonal psychotherapy (IPT), imipramine plus clinical management (IMI-CM), and placebo plus clinical management (PLA-CM).

Initial Severity: A Key Factor in Treatment Response

The analysis revealed that initial severity of depression significantly predicted differential treatment effects. The more severely ill patients showed greater differences in response to the active treatments compared to those with less severe depression. This finding highlights the importance of considering initial severity when selecting a treatment approach for major depressive disorder.

A Camel's Guidance: Tailoring Treatment to Individual Needs

The desert of depression can be vast and challenging, and it's essential to find a treatment path that is tailored to your individual needs. This study emphasizes the importance of considering initial severity when choosing a treatment approach, as it significantly influences treatment outcomes. Remember, there are many oases of relief waiting to be discovered, and working closely with a healthcare professional can help you find the most effective path for your journey.

Dr. Camel's Conclusion

This research highlights the importance of tailoring depression treatment to individual needs, recognizing that initial severity plays a significant role in treatment response. By carefully assessing the severity of depression and choosing the appropriate treatment approach, we can help individuals navigate the challenging desert of mental illness and find pathways to healing and well-being. Remember, we are all travelers in this vast desert, and working together can help us find oases of support and hope along the way.

Date :
  1. Date Completed 1995-12-28
  2. Date Revised 2023-03-06
Further Info :

Pubmed ID

7593878

DOI: Digital Object Identifier

10.1037//0022-006x.63.5.841

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・Effective treatment of depression
SNS
PICO Info
in preparation
Languages

English

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