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The acute effects of zolpidem, administered alone and with alcohol, on cognitive and psychomotor function.

Author: WilkinsonC J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study found that alcohol did not appear to potentiate the effects of zolpidem on performance skills. Some additive effects of alcohol were seen with the lower 10-mg dose of zolpidem, but no nonadditive effects were found.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Skills performance impairment after acute doses of zolpidem (a short-acting, nonbenzodiazepine hypnotic), alone and with alcohol, was evaluated in 24 subjects. The study was designed to test whether the effects of zolpidem and alcohol are simply additive or reflect potentiation. METHOD:...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7615484

データ提供：米国国立医学図書館（NLM）

Zolpidem and Alcohol: Examining Their Combined Effects on Cognitive Function

Zolpidem, a short-acting hypnotic, is commonly used to treat insomnia. However, combining zolpidem with alcohol can have significant consequences for cognitive function and psychomotor skills. This research investigates the effects of zolpidem, both alone and in combination with alcohol, on cognitive performance in healthy male volunteers. The study uses a randomized crossover design to assess the effects of different doses of zolpidem and alcohol on a battery of cognitive tasks, including divided attention, information processing rate, immediate memory, and sustained attention.

Zolpidem and Alcohol: Additive Effects on Cognitive Performance

The study's findings demonstrate that both alcohol and zolpidem, individually and in combination, significantly impair cognitive performance during the peak effect period. Notably, the study observed additive effects of alcohol with zolpidem, suggesting that their combined effects on cognitive function are more pronounced than those seen with either substance alone.

Zolpidem and Alcohol: A Reminder of the Importance of Responsible Use

This research highlights the importance of avoiding the combined use of zolpidem and alcohol. The study's findings suggest that combining these substances can significantly impair cognitive function and increase the risk of accidents or injury.

Dr.Camel's Conclusion

This research provides valuable insights into the combined effects of zolpidem and alcohol on cognitive performance. It underscores the importance of avoiding the combination of these substances, as it can significantly impair cognitive function and increase the risk of accidents or injury.

Date :
  1. Date Completed 1995-08-24
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

7615484

DOI: Digital Object Identifier

7615484

Related Literature

Article Analysis
・Effects of zolpidem・Effects of ulipristal
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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