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A controlled trial of zidovudine in primary human immunodeficiency virus infection.

Author: CarrA, ClumeckN, CooperD A, HirschelB J, HoenB, Kinloch-De LoësS, LazzarinA, MathiesenL, SauratJ H, TindallB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Antiretroviral therapy administered during primary HIV infection may improve the subsequent clinical course and increase the CD4 cell count. Disease progression was significantly less frequent in the zidovudine group than in the placebo group.
Paper Details　
Original Abstract of the Article :
BACKGROUND: It is possible that antiretroviral treatment given early during primary infection with the human immunodeficiency virus (HIV) may reduce acute symptoms, help preserve immune function, and improve the long-term prognosis. METHODS: To assess the effect of early antiviral treatment, we con...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://doi.org/10.1056/NEJM199508173330702

データ提供：米国国立医学図書館（NLM）

Early Intervention in HIV: A Game Changer

The world of HIV research is constantly seeking new ways to combat the virus. This study explores the potential of early antiviral treatment with zidovudine in individuals newly infected with HIV. The research aims to assess the impact of early intervention on acute symptoms, immune function, and long-term prognosis. The researchers designed a double-blind, placebo-controlled trial to determine the effectiveness of zidovudine in combating the virus.

Early Intervention: A Potential Oasis

The study reveals that early antiviral treatment with zidovudine shows promise in improving the clinical course of primary HIV infection. Like finding a watering hole in a barren desert, early intervention offers a chance for individuals to manage their health and improve their long-term outlook. The research suggests that zidovudine can help control disease progression, increase the CD4 cell count, and potentially reduce the risk of opportunistic infections.

Navigating the HIV Landscape

This study provides valuable insights for HIV treatment strategies. Early intervention, like a well-timed camel caravan, can significantly impact the course of the disease. The findings highlight the importance of early diagnosis, prompt treatment, and ongoing monitoring to manage HIV effectively.

Dr. Camel's Conclusion

Early intervention in HIV infection, like finding a spring in the desert, offers a vital opportunity to manage the disease and improve patient outcomes. The research emphasizes the potential benefits of early antiviral therapy and underscores the importance of ongoing research and development in this field.

Date :
  1. Date Completed 1995-08-24
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7616989

DOI: Digital Object Identifier

10.1056/NEJM199508173330702

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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