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Why imidazoline receptor modulator in the treatment of hypertension?

Author: ChristenM O, KaanE C, Löw-KrögerA, MestH J, MolderingsG J, SchäferS G

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Moxonidine, a second-generation centrally acting antihypertensive drug, selectively targets I1-imidazoline receptors, leading to blood pressure lowering with fewer side effects than first-generation drugs.
Paper Details　
Original Abstract of the Article :
The influence of the sympathetic nervous system on blood pressure control was impressively demonstrated in 1940 by bilateral excision of sympathetic nerve fibers. Thereafter, the first generation of drugs lowering blood pressure by central modulation of the sympathetic outflow through alpha 2-adreno...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1749-6632.1995.tb32460.x

データ提供：米国国立医学図書館（NLM）

Imidazoline Receptor Modulators: A New Frontier in Hypertension Treatment

Hypertension, or high blood pressure, is a major public health concern, affecting millions worldwide. This research explores the role of imidazoline receptor modulators in treating hypertension. Imidazoline receptors are a recently discovered class of receptors that play a role in regulating blood pressure. The researchers examined the efficacy and safety of moxonidine, an I1-imidazoline receptor modulator, in treating hypertension. The study found that moxonidine effectively lowered blood pressure with fewer side effects compared to older centrally acting antihypertensive drugs.

Targeted Treatment for Hypertension

This research highlights the potential of I1-imidazoline receptor modulators, like moxonidine, in treating hypertension. The study demonstrated that moxonidine effectively reduced blood pressure with a lower incidence of side effects compared to older medications. This targeted approach offers a promising new avenue for hypertension management.

Navigating Hypertension: Lifestyle and Medications

Managing hypertension requires a multifaceted approach, including lifestyle modifications and medication if necessary. Maintaining a healthy diet, regular exercise, and managing stress can all help control blood pressure. Consult with a healthcare professional to determine the best treatment plan for your individual needs.

Dr. Camel's Conclusion

Hypertension can be a daunting challenge, but research is constantly unveiling new pathways to effective treatment. This study highlights the potential of Imidazoline receptor modulators, like moxonidine, in offering a targeted approach to hypertension management. Remember, a healthy lifestyle combined with appropriate medical care can help you traverse the path towards a healthier and happier life.
Date :
  1. Date Completed 1995-10-18
  2. Date Revised 2019-06-16
Further Info :

Pubmed ID

7677385

DOI: Digital Object Identifier

10.1111/j.1749-6632.1995.tb32460.x

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