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A new chemotherapy regimen for treatment of Hodgkin's disease associated with minimal genotoxicity.

Author: BaileyN M, CabanillasF F, FullerL M, GabrielG J, HagemeisterF B, KattanM W, LiangJ C, WangR Y

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

The combination chemotherapy NOVP (Novantrone, Oncovin, Velban, Prednisone) did not induce chromosome breaks, single-stranded DNA breaks, or sister chromatid exchanges in lymphocytes of Hodgkin's disease patients, suggesting it is less genotoxic than MOPP.
Paper Details　
Original Abstract of the Article :
Recently, the combination chemotherapy Novantrone, Oncovin, Velban, Prednisone [NOVP] was developed by The University of Texas M. D. Anderson Cancer Center for treatment of Hodgkin's disease [HD]. Preliminary clinical results show that NOVP is as effective as the traditional Mechlorethamine, Oncovin...See full text at original site
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引用元：
https://doi.org/10.3109/10428199309145757

データ提供：米国国立医学図書館（NLM）

A New Chemotherapy Regimen for Hodgkin's Disease: NOVP

This research explores the potential of a new chemotherapy regimen, called NOVP, for treating Hodgkin's disease (HD), a type of cancer that affects the lymphatic system. The researchers aimed to determine the effectiveness and toxicity of NOVP compared to the traditional MOPP regimen. They found that NOVP was as effective as MOPP in achieving remission but with fewer side effects. The researchers also investigated the genotoxicity of NOVP, looking for any potential damage to DNA. They found that NOVP caused minimal genotoxicity, suggesting a safer alternative to MOPP.

A Safer Alternative: Navigating the Chemotherapy Desert

The study demonstrates the potential of NOVP as a safer and more effective treatment option for Hodgkin's disease. The researchers' findings suggest that NOVP could be a valuable tool in the fight against this type of cancer. It's like finding a new pathway through the desert, offering a safer and more efficient route to treatment.

Hope for Patients: A Journey Toward Recovery

The research provides hope for patients with Hodgkin's disease, offering a potentially safer and more effective treatment option. The findings emphasize the importance of ongoing research and development in the field of cancer treatment, constantly seeking new and improved approaches to combat this challenging disease.

Dr.Camel's Conclusion

This research highlights the potential of a new chemotherapy regimen, NOVP, as a safer and more effective alternative to the traditional MOPP regimen for treating Hodgkin's disease. The findings underscore the importance of ongoing research and development in the field of cancer treatment, constantly striving for better and safer treatment options for patients.

Date :
  1. Date Completed 1993-09-02
  2. Date Revised 2019-01-16
Further Info :

Pubmed ID

7687918

DOI: Digital Object Identifier

10.3109/10428199309145757

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・Side Effects of mechlorethamine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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