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Thyroid function test changes with adjuvant tamoxifen therapy in postmenopausal women with breast cancer.

Author: LeeK E, LoveR R, MambyC C

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Tamoxifen therapy in postmenopausal women resulted in increased thyroid-binding globulin (TBG), leading to secondary increases in measured thyroxine uptake (T-Uptake) and thyroxine (T4). However, thyroid-stimulating hormone (TSH) and free T4 index (FTI) levels remained unchanged, suggesting that treated women remain eumetabolic.
Paper Details　
Original Abstract of the Article :
PURPOSE: While tamoxifen has been shown to alter concentration of many hormones and their binding globulins, there have been conflicting results regarding its effects on thyroid function tests. We sought to clarify these effects by studying subjects in a controlled clinical trial. PATIENTS AND METH...See full text at original site
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引用元：
https://doi.org/10.1200/JCO.1995.13.4.854

データ提供：米国国立医学図書館（NLM）

Tamoxifen and Thyroid Function: A Journey Through Hormone Changes

Tamoxifen is a commonly used medication for breast cancer, but it can have complex effects on the body, especially on hormone levels. This study examined the effects of tamoxifen on thyroid function tests in postmenopausal women with breast cancer. The researchers compared the thyroid function tests of women who received tamoxifen to those who received a placebo.

Tamoxifen's Effects on Thyroid Function: A Desert Oasis of Knowledge

The study found that tamoxifen significantly increased thyroid-binding globulin (TBG), leading to secondary increases in thyroxine uptake (T-Uptake) and thyroxine (T4). However, the levels of thyroid-stimulating hormone (TSH) and free T4 index (FTI) remained unchanged, indicating that the women remained eumetabolic (having normal thyroid function). These findings provide valuable insights into the hormonal interactions of tamoxifen and its effects on thyroid function.

Navigating the Desert of Hormone Interactions

The study suggests that tamoxifen therapy in postmenopausal women can lead to hormonal changes that affect thyroid function tests. However, the authors conclude that these changes do not necessarily indicate an underlying thyroid problem. It's important to monitor thyroid function tests regularly during tamoxifen therapy to ensure optimal health and well-being.

Dr.Camel's Conclusion

The desert of hormone interactions can be a complex and often confusing landscape. This study helps us understand the specific interactions between tamoxifen and thyroid function, providing valuable insights for clinicians and patients alike. By navigating this desert with a keen eye and a good understanding of the hormonal interplay, we can ensure a smooth journey and optimal health for those who need tamoxifen therapy.

Date :
  1. Date Completed 1995-05-10
  2. Date Revised 2017-02-10
Further Info :

Pubmed ID

7707111

DOI: Digital Object Identifier

10.1200/JCO.1995.13.4.854

Related Literature

Article Analysis
・Effects of tamoxifen・Effects of thyroid
SNS
PICO Info
in preparation
Languages

English

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