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Colour vision and side-effects during treatment with methazolamide.

Author: MandahlA, TörnquistP, WidengårdI, WistrandP J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Methazolamide, a carbonic anhydrase inhibitor, caused color vision problems in 8 out of 14 volunteers. The issue was not related to acidosis or other side effects, suggesting that CA inhibition specifically affects the retina or visual cortex.
Paper Details　
Original Abstract of the Article :
The retina contains Na+K(+)-ATPase and carbonic anhydrase (CA), enzymes that regulate ion fluxes across cell membranes of photoreceptors. Since inhibition of retinal Na+K(+)-ATPase by digitalis impairs colour vision, we wanted to find out whether this also occurs after inhibition of CA. In a double-...See full text at original site
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引用元：
https://doi.org/10.1038/eye.1995.22

データ提供：米国国立医学図書館（NLM）

Methazolamide and Color Vision: A Journey Through the Desert of Retinal Physiology

Carbonic anhydrase (CA) inhibitors, such as methazolamide, are commonly used to treat glaucoma, a condition characterized by increased intraocular pressure. This study investigates the potential effects of methazolamide on color vision, exploring whether inhibition of CA in the retina might impair color perception. The researchers conducted a double-masked crossover study, evaluating color discrimination in healthy volunteers after administration of methazolamide.

A Subtle Shift in the Desert of Perception: Methazolamide's Effects on Color Vision

The study found that methazolamide administration was associated with disturbances in color discrimination in a significant proportion of participants. This finding suggests a potential effect of CA inhibition on retinal function, potentially impacting color perception. However, the study did not find a correlation between the presence of color vision disturbances and the degree of acidosis or other side effects, suggesting a more specific effect of CA inhibition on retinal function.

Navigating the Desert of Perception: Balancing Benefits and Risks

This study highlights the potential of CA inhibitors like methazolamide to impact color vision, reminding us that even seemingly targeted interventions can have subtle effects on other aspects of physiological function. While these medications are effective in managing glaucoma, the potential for color vision disturbances should be considered when weighing the benefits and risks of treatment. This underscores the importance of ongoing monitoring and open communication between patients and healthcare providers to ensure optimal treatment outcomes.

Dr.Camel's Conclusion

This study reveals a potential for CA inhibitors like methazolamide to impact color vision, suggesting that even seemingly targeted interventions can have unexpected consequences. As we navigate the vast desert of retinal physiology, we must remain vigilant to the potential effects of medications on various aspects of visual function.

Date :
  1. Date Completed 1995-05-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7713242

DOI: Digital Object Identifier

10.1038/eye.1995.22

Related Literature

Article Analysis
・Side Effects of methazolamide
SNS
PICO Info
in preparation
Languages

English

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