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A prospective evaluation of the roles of allogeneic marrow transplantation and low-dose monthly maintenance chemotherapy in the treatment of adult acute myelogenous leukemia (AML): a Southwest Oncology Group study.

Author: BalcerzakS P, BickersJ N, DabichL, EliasL, EyreH J, HeadD, HewlettJ, HynesH, KingsburyL, KopeckyK J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

In a study of 522 people with acute myeloid leukemia (AML), 57% achieved complete remission (CR). Those younger than 50 years old had a higher remission rate (70%). 39% of patients had a suitable donor for a bone marrow transplant, and two-thirds of those received a transplant in their first remission. 5-year disease-free survival was similar for those who received a transplant, those with a donor who did not receive a transplant, and those without a donor (41%, 42%, and 29%, respectively). Monthly maintenance therapy was associated with prolonged disease-free survival, but not improved overall survival. Factors associated with improved overall survival included younger age, lower white blood cell count at diagnosis, having a specific type of leukemia (M3 morphology), and being white. People with M3 AML had particularly favorable outcomes, with 75% disease-free survival and 56% overall survival at 7 years.
Paper Details　
Original Abstract of the Article :
Between February 1982 and December 1986, the Southwest Oncology Group conducted a prospective study in patients with newly diagnosed acute myeloid leukemia (AML) with two objectives: to evaluate the role of allogeneic marrow transplantation for patients in first remission, and to evaluate the role o...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/7723385

データ提供：米国国立医学図書館（NLM）

Navigating the Shifting Sands of AML Treatment

Imagine a vast, shifting desert of cancer cells, constantly changing and adapting. Acute myelogenous leukemia (AML) is a complex and aggressive cancer that requires a multi-pronged approach to treatment. This research delves into the effectiveness of two different strategies: allogeneic marrow transplantation and low-dose maintenance chemotherapy.

The researchers conducted a prospective study to evaluate the role of these treatments in patients newly diagnosed with AML. They found that allogeneic marrow transplantation, a procedure where healthy bone marrow cells are transplanted from a donor, showed promising results in patients who achieved complete remission. However, low-dose monthly maintenance therapy, administered to patients who didn't receive a transplant, also showed a positive impact, prolonging the disease-free survival time.

The researchers also discovered that factors like age, white blood cell count at diagnosis, and specific subtypes of AML influenced treatment outcomes. For example, patients with M3 AML, a specific subtype of AML, showed particularly favorable responses to treatment.

Finding Oasis in the Desert of AML

This research highlights the need for personalized approaches to AML treatment. While allogeneic marrow transplantation offers significant benefits for certain patients, low-dose maintenance chemotherapy can also be effective in managing the disease. The study emphasizes the importance of considering individual patient factors when determining the optimal treatment plan.

Adapting to the Shifting Sands

AML is a challenging disease, and finding the right treatment approach is crucial. This research provides valuable insights into the effectiveness of different treatment strategies and the importance of individualized care. As we continue to explore the shifting sands of AML research, we hope to develop even more effective treatments and improve patient outcomes.

Dr.Camel's Conclusion

This research underscores the importance of ongoing research and innovation in the field of AML treatment. By adapting to the shifting sands of the disease, we can develop more effective treatments and improve the lives of those battling this challenging condition.

Date :
  1. Date Completed 1995-05-23
  2. Date Revised 2013-03-04
Further Info :

Pubmed ID

7723385

DOI: Digital Object Identifier

7723385

SNS
PICO Info
in preparation
Languages

English

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