Low Pentasa dosage versus hydrocortisone in the topical treatment of active ulcerative colitis: a randomized, double-blind study.

Author: ArdizzoneS, Bianchi PorroG, FasoliA, ImbesiV, MolteniP, PetrilloM

Paper Details 
Original Abstract of the Article :
OBJECTIVES: To compare a low dosage (1 g/day) rectal preparation of 5-aminosalicylic acid in slightly acidic, buffered suspension (Pentasa) with a hydrocortisone 100 mg/day enema (Cortenema). METHODS: Fifty-two patients with mild to moderate distal ulcerative colitis were randomized under double-bl...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/7733079

データ提供:米国国立医学図書館(NLM)

Low Pentasa Dosage Versus Hydrocortisone in Topical Treatment of Active Ulcerative Colitis

This study delves into the world of ulcerative colitis (UC), comparing the effectiveness of two topical treatments: low-dose Pentasa, a medication containing 5-aminosalicylic acid, and hydrocortisone enemas. Picture this: UC is like a desert mirage, where the gut lining is inflamed and irritated, causing pain and discomfort. The researchers wanted to determine if low-dose Pentasa could be just as effective as hydrocortisone in controlling these symptoms. They conducted a double-blind study, where patients received either Pentasa or hydrocortisone enemas for three weeks. Their findings revealed that both treatments led to significant improvements in clinical and endoscopic activity, with no significant difference in efficacy between the two. The study highlights the potential of low-dose Pentasa as a viable treatment option for UC, offering a gentler and potentially more tolerable approach.

Finding Relief for Ulcerative Colitis

This study offers hope for individuals suffering from UC, demonstrating that low-dose Pentasa can provide effective symptom relief comparable to hydrocortisone enemas. The researchers found no significant difference in efficacy between the two treatments, suggesting that low-dose Pentasa could be a valuable alternative for patients seeking a more tolerable treatment option. It's like finding a hidden oasis in the desert, offering a refreshing and effective solution for those struggling with the challenges of UC.

Navigating Ulcerative Colitis Treatment

This research underscores the importance of personalized treatment approaches for UC, considering both efficacy and tolerability. The authors emphasize the value of low-dose Pentasa as a viable alternative for patients seeking a gentler treatment option. It's like choosing the best path through a desert, carefully considering the terrain and potential challenges to find the most comfortable and effective route.

Dr. Camel's Conclusion

This study provides valuable insights into the treatment of ulcerative colitis, demonstrating that low-dose Pentasa is a viable and effective alternative to hydrocortisone enemas. The findings highlight the importance of personalized treatment approaches that consider both efficacy and tolerability, offering patients a range of options to find the best solution for their individual needs.
Date :
  1. Date Completed 1995-06-01
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

7733079

DOI: Digital Object Identifier

7733079

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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