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Management of early cancer of the breast. Report on an international multicentre trial supported by the Cancer Research Campaign.

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Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A large controlled clinical study comparing radical mastectomy with radiotherapy to simple mastectomy alone found that postoperative radiotherapy reduced the incidence of local recurrence but did not improve survival or distant recurrence.
Paper Details　
Original Abstract of the Article :
In the largest controlled clinical study so far undertaken on the management of early cancer of the breast in women the results of a radical regimen (simple mastectomy and radiotherapy) were compared with those of a conservative policy (simple mastectomy alone). The study included enough patients (2...See full text at original site
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引用元：
https://doi.org/10.1136/bmj.1.6017.1035

データ提供：米国国立医学図書館（NLM）

Management of Early Cancer of the Breast: A Multi-Centre Trial

This research, employing a large-scale multi-centre trial, investigated the effectiveness of different treatment strategies for early breast cancer. The study compared a radical regimen (simple mastectomy and radiotherapy) to a conservative approach (simple mastectomy alone) in a group of 2268 women. The results indicated that routine postoperative radiotherapy did not significantly impact survival or distant recurrence rates. However, it did reduce the incidence of local recurrence. This research suggests that a conservative approach with adjuvant chemotherapy might be the preferred option for managing early breast cancer.

Radiotherapy for Early Breast Cancer: A Balancing Act

This study provides valuable insights into the role of radiotherapy in managing early breast cancer. While it was found to be effective in reducing local recurrence, it did not significantly impact survival or distant recurrence rates. This suggests that a conservative approach with adjuvant chemotherapy might be an effective alternative. Further research is crucial to determine the optimal balance between radiotherapy and chemotherapy in managing this complex disease.

Navigating the Labyrinth of Breast Cancer: Finding the Best Path

Imagine early breast cancer as a labyrinth, a complex network of potential treatments and outcomes. This research provides crucial insights into the most effective pathways for navigating this labyrinth, suggesting that a conservative approach with adjuvant chemotherapy might offer a smoother and potentially more effective journey. This highlights the need for a personalized approach, carefully considering each patient's individual circumstances and treatment goals.

Dr.Camel's Conclusion

This large-scale multi-centre trial sheds light on the effectiveness of different approaches to managing early breast cancer. While radiotherapy was found to be beneficial in reducing local recurrence, it did not significantly impact survival or distant recurrence rates. The research suggests that a conservative approach with adjuvant chemotherapy may be a more effective option, but further research is needed to determine the optimal balance between these treatment strategies.

Date :
  1. Date Completed 1976-08-02
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

773497

DOI: Digital Object Identifier

10.1136/bmj.1.6017.1035

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

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