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One-year acarbose treatment raises fasting serum acetate in diabetic patients.

Author: ChiassonJ L, HuntJ A, JosseR G, PalmasonC, RadmardR, RodgerN W, RossS A, RyanE A, TanM H, WoleverT M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Acarbose treatment increased serum acetate in diabetic patients, but this change was unrelated to side effects or changes in blood glucose control or serum lipids.
Paper Details　
Original Abstract of the Article :
alpha-Glucosidase inhibitors such as acarbose improve blood glucose control in diabetes by delaying or reducing carbohydrate absorption. The fermentation of malabsorbed carbohydrate in the colon is associated with the production of gas, leading to flatulence, and short chain fatty acids such as acet...See full text at original site
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引用元：
https://doi.org/10.1111/j.1464-5491.1995.tb00448.x

データ提供：米国国立医学図書館（NLM）

Investigating the Impact of Acarbose on Fasting Serum Acetate Levels in Diabetic Patients

This research explores the effects of acarbose, an alpha-glucosidase inhibitor, on fasting serum acetate levels in diabetic patients. The study, conducted over a one-year period, utilized a double-blind, placebo-controlled, parallel design. The results demonstrated that acarbose treatment significantly increased fasting serum acetate levels compared to placebo. The authors also found that acarbose effectively improved blood glucose control, as indicated by a reduction in HbA1C levels. The study concludes that acarbose treatment elevates serum acetate levels in diabetic patients, but this change was not associated with adverse effects or changes in blood glucose control or serum lipids.

Understanding the Potential Impact of Acarbose on Serum Acetate Levels

This research provides valuable insights into the metabolic effects of acarbose, an alpha-glucosidase inhibitor commonly used to manage diabetes. The findings suggest that acarbose can significantly increase serum acetate levels, a byproduct of carbohydrate fermentation in the colon. While this change is not associated with adverse effects, it's important to monitor serum acetate levels in patients receiving acarbose treatment.

Navigating the Potential Side Effects of Diabetes Medications

This research highlights the importance of considering the potential metabolic side effects of diabetes medications. While acarbose has been shown to effectively improve blood glucose control, it can also increase serum acetate levels. It's crucial to discuss any potential side effects with your physician to make informed decisions about your treatment plan.

Dr. Camel's Conclusion

This research reminds me of the delicate balance of the desert ecosystem, where even seemingly small changes can have cascading effects. Just as a shift in the desert wind can alter the landscape, acarbose treatment can influence serum acetate levels. This study underscores the importance of understanding the complex interactions between medications and our bodies to optimize treatment strategies.
Date :
  1. Date Completed 1995-06-09
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

7743764

DOI: Digital Object Identifier

10.1111/j.1464-5491.1995.tb00448.x

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Languages

English

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