Effects of acarbose: A Synthesis of Findings from 8 Studies

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Original Abstract of the Article

Major Research Findings

Acarbose is an alpha-glucosidase inhibitor, which works by slowing down the absorption of sugar from food, thereby reducing blood sugar spikes. 8 These studies compared the adverse effects, particularly gastrointestinal side effects, of acarbose and miglitol. 8 Acarbose has been shown to be effective in reducing postprandial hyperglycemia by slowing down the absorption of sugar from food. 6 Moreover, acarbose has been reported to decrease postprandial triglyceride levels. 4 Acarbose has also been shown to be effective as an adjunctive therapy in combination with other diabetes medications, such as diet therapy and sulfonylureas. 5 Acarbose is considered a safe and effective drug for controlling blood sugar levels and can be used in combination with other diabetes medications. 1 Acarbose is expected to not only suppress postprandial blood sugar spikes but also improve blood lipid levels. 2 However, acarbose can cause gastrointestinal side effects, such as abdominal bloating, gas, and diarrhea. 3 Acarbose is not thought to significantly impact dietary habits and is not expected to alter eating patterns. 7 Acarbose has the potential to improve blood sugar control and blood lipid levels in diabetes management, but it is essential to consider the possibility of gastrointestinal side effects.

Benefits and Risks

Benefits Summary

Acarbose is expected to suppress blood sugar spikes and decrease postprandial triglyceride levels. 6 4 It has also been shown to be effective as an adjunctive therapy in combination with other diabetes medications, such as diet therapy and sulfonylureas. 5 Acarbose is considered a safe and effective drug for controlling blood sugar levels and can be used in combination with other diabetes medications. 1

Risks Summary

Acarbose can cause gastrointestinal side effects, such as abdominal bloating, gas, and diarrhea. 3

Comparison Between Studies

Commonalities in Studies

All these studies suggest that acarbose is an effective drug for managing diabetes. 8 6 4 5 1 2 3 7 Additionally, all these studies suggest that acarbose can cause gastrointestinal side effects. 8 3

Differences in Studies

These studies differ in several aspects, including the timing and dosage of acarbose, the study population, etc. 8 6 4 5 1 2 3 7 Moreover, these studies show some different findings regarding the efficacy and side effects of acarbose. 8 6 4 5 1 2 3 7 These studies suggest the need for further research on the effects and side effects of acarbose.

Consistency and Contradictions in Results

These studies suggest that acarbose is an effective drug for managing diabetes, but they show some different findings regarding the efficacy and side effects of acarbose. 8 6 4 5 1 2 3 7 These studies suggest the need for further research on the effects and side effects of acarbose.

Considerations for Real-Life Application

Acarbose has been shown to be effective in reducing postprandial hyperglycemia by slowing down the absorption of sugar from food. 6 However, acarbose can cause gastrointestinal side effects, such as abdominal bloating, gas, and diarrhea. 3 These side effects should be considered when taking acarbose.

Limitations of Current Research

These studies suggest the need for further research on the effects and side effects of acarbose. 8 6 4 5 1 2 3 7 For instance, these studies did not investigate the long-term effects and side effects of acarbose.

Future Research Directions

Long-term studies on the effects and side effects of acarbose are needed. 8 6 4 5 1 2 3 7 Further research is also required to better understand the effects and side effects of acarbose.

Conclusion

These studies suggest that acarbose is an effective drug for managing diabetes, but they show some different findings regarding the efficacy and side effects of acarbose. 8 6 4 5 1 2 3 7 If you are considering taking acarbose, it is important to consult with your doctor and fully understand the risks and benefits of the medication.

Literature analysis of 8 papers
Positive Content
8
Neutral Content
0
Negative Content
0
Article Type
8
0
0
1
8
1.

Effects of acarbose on carbohydrate metabolism, electrolytes, minerals and vitamins in fairly well-controlled non-insulin-dependent diabetes mellitus.

Author: Van GaalL, NobelsF, De LeeuwI

Controls diabetes
Safe for long-term use
Bloating
Gas

Acarbose, an alpha-glucosidase inhibitor, demonstrated a slight beneficial effect on diabetic metabolic control in 24 non-insulin-dependent diabetics. Acarbose treatment significantly lowered HbA1c levels and urinary glucose excretion compared to placebo. No major side effects were reported, but meteorism and flatulence were common complaints.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Beneficial effects on serum lipids in noninsulin dependent diabetics by acarbose treatment.

Author: LeonhardtW, HanefeldM, FischerS, SchulzeJ, SpenglerM

Controls diabetes
Lowers cholesterol
Lowers triglycerides

Acarbose, an alpha-glucosidase inhibitor, effectively lowers blood glucose and insulin levels, especially in the postprandial state, and improves HbA1c levels in patients with noninsulin-dependent diabetes mellitus (NIDDM). Acarbose treatment also significantly reduced elevated cholesterol concentrations and postprandial triglyceride concentrations in NIDDM patients compared to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

3.

One-year acarbose treatment raises fasting serum acetate in diabetic patients.

Author: WoleverT M, RadmardR, ChiassonJ L, HuntJ A, JosseR G, PalmasonC, RodgerN W, RossS A, RyanE A, TanM H

Blood glucose control
HbA1C reduction
Flatulence

Acarbose treatment increased serum acetate in diabetic patients, but this change was unrelated to side effects or changes in blood glucose control or serum lipids.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Efficacy of alpha-glucosidase inhibitors on lipids in NIDDM subjects with moderate hyperlipidaemia.

Author: LeonhardtW, HanefeldM, FischerS, SchulzeJ

Plasma lipid improvement

This study reviewed the effects of acarbose, an alpha-glucosidase inhibitor, on plasma lipid concentrations. Acarbose was found to reduce triglyceride levels and potentially improve lipid profiles in patients with high initial cholesterol levels.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

5.

[Effectiveness and tolerance of long-term acarbose therapy in diabetic patients with threatened secondary failure of sulfonylurea drug treatment].

Author: DomkeA, WillmsB

Improved diabetic control
Safe
Flatulence
Meteorism

This study investigated the efficacy and tolerability of acarbose in type-2-diabetic patients poorly controlled with diet and sulfonylureas. Acarbose improved diabetic control and was well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : German

6.

The effect of the timing and the administration of acarbose on postprandial hyperglycaemia.

Author: RosakC, NitzscheG, KönigP, HofmannU

Blood glucose control
Hypoglycemia

Acarbose, an oral hypoglycemic agent, is most effective when taken with the first mouthful of food for patients with Type 2 diabetes. Taking acarbose 30 minutes before a meal resulted in higher blood glucose increases.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Acarbose treatment does not change the habitual diet of patients with Type 2 diabetes mellitus. The Finnish Acargbos Study Group.

Author: LindströmJ, TuomilehtoJ, SpenglerM

Improved metabolic control
Adverse gastrointestinal effects

Acarbose can improve metabolic control in patients with Type 2 diabetes mellitus, but this may be due to changes in diet rather than the drug itself.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

8.

Comparison of adverse gastrointestinal effects of acarbose and miglitol in healthy men: a crossover study.

Author: AokiKazutaka, MuraokaTomonori, ItoYuzuru, TogashiYu, TerauchiYasuo

Gastrointestinal adverse effects

This study compared the incidence of gastrointestinal adverse effects with acarbose and miglitol, two alpha-glucosidase inhibitors used for the treatment of type 2 diabetes. The study aimed to address the lack of direct investigation on the adverse effects of these drugs and contribute to understanding their safety profiles.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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