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Differential effects of chloral hydrate and pentobarbital sodium on a cocaine level and its catecholamine response in the medial prefrontal cortex: a comparison with conscious rats.

Author: ChenN H, LaiY J, PanW H

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Anesthetics can suppress neuronal responses to cocaine. Chloral hydrate does not significantly suppress cocaine-induced catecholamine responses in the medial prefrontal cortex, while pentobarbital sodium does.
Paper Details　
Original Abstract of the Article :
Adult male Sprague-Dawley rats anesthetized with chloral hydrate and pentobarbital sodium were used as two different treatment groups. Conscious rats were used as a control group. By using baseline (precocaine) concentration as 100%, after cocaine administration (3.0 mg/kg i.v.), the maximal dopamin...See full text at original site
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引用元：
https://doi.org/10.1046/j.1471-4159.1995.64062653.x

データ提供：米国国立医学図書館（NLM）

Anesthetics and Cocaine: A Complex Interaction

The field of [neuropharmacology] is constantly exploring the intricate interplay between [anesthetics] and [drugs of abuse], with the aim of understanding their impact on the brain. This study investigated the differential effects of [chloral hydrate and pentobarbital sodium] on [cocaine levels] and their associated [catecholamine response] in the [medial prefrontal cortex] of rats.

Unraveling the Influence of Anesthetics on Cocaine Effects

The study revealed that [chloral hydrate] resulted in a significantly higher [maximal dopamine (DA) increase] compared to [pentobarbital sodium], while [norepinephrine (NA) increases] were also higher in the [chloral hydrate] group. Moreover, [cocaine concentrations] were higher over a longer period of time in the [chloral hydrate] group, suggesting that this anesthetic may have a more profound impact on the [pharmacokinetic] profile of [cocaine].

A Balancing Act: Understanding the Complex Interaction

These findings highlight the complex interplay between [anesthetics] and [cocaine] in the brain. While [pentobarbital sodium] appears to suppress the [pharmacological response] of neurons, [chloral hydrate] may exhibit a balancing effect between [increased cocaine levels] and [anesthetic suppression] on [neuronal activity]. This study offers valuable insights into the mechanisms by which [anesthetics] influence the effects of [cocaine] in the brain.

Dr.Camel's Conclusion

The study of [anesthetics and cocaine] is like navigating a desert of intricate biological pathways, where each element plays a crucial role in determining the overall impact on the brain. This study sheds light on the complex interplay between these substances, emphasizing the need for careful consideration of the effects of [anesthetics] on the [pharmacological response] of [cocaine].

Date :
  1. Date Completed 1995-06-28
  2. Date Revised 2019-06-30
Further Info :

Pubmed ID

7760045

DOI: Digital Object Identifier

10.1046/j.1471-4159.1995.64062653.x

Related Literature

Article Analysis
・Effects of chloral hydrate
SNS
PICO Info
in preparation
Languages

English

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