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Comparison of CNS adverse effects between astemizole and chlorpheniramine in children: a randomized, double-blind study.

Author: FeldmanW, LeikinL, PetersonR, PongA H, ShanonA, WilliamsV

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Chlorpheniramine and astemizole had no adverse effects on the performance of children in a study of central nervous system side effects.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To assess the central nervous system side effects of chlorpheniramine and astemizole in children. DESIGN: Prospective, randomized, double-blind cross-over study. SETTING: Children were recruited from the out-patient allergy clinic and from respondents to an advertisement in a local news...See full text at original site
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引用元：
https://doi.org/10.1159/000457568

データ提供：米国国立医学図書館（NLM）

Comparing the CNS Effects of Astemizole and Chlorpheniramine in Children

This study investigates the potential central nervous system (CNS) side effects of two antihistamines, astemizole and chlorpheniramine, in children. The researchers conducted a prospective, randomized, double-blind cross-over study with children 8-16 years of age who had isolated allergic rhinitis or hay fever. The study evaluated various aspects of cognitive function, motor coordination, and physical side effects. The results showed that neither astemizole nor chlorpheniramine had significant adverse effects on the performance of children in the study. Both medications were well-tolerated, with no clinically significant differences in adverse effects observed between the two.

No Significant CNS Side Effects for Astemizole and Chlorpheniramine

The study provides reassuring evidence that astemizole and chlorpheniramine do not have significant CNS side effects in children. This finding is important for parents and healthcare providers, as it supports the use of these antihistamines for the relief of allergic rhinitis in children. The study's results suggest that these medications can be safely administered without causing any significant cognitive or motor impairments.

Safety and Efficacy of Antihistamines in Children

This research emphasizes the importance of understanding the safety and efficacy of medications, particularly in vulnerable populations like children. The study's findings can help guide healthcare providers in making informed decisions about the use of antihistamines for allergic rhinitis in children. It is always essential to consult with a healthcare professional to discuss the potential risks and benefits of any medication before administering it to a child.

Dr. Camel's Conclusion

This study is like a clear oasis in the desert of potential side effects. The researchers have shown that these antihistamines can be safely administered to children, giving us peace of mind. This study serves as a beacon of hope for parents and children, reminding us that effective treatments for allergies can be safe and well-tolerated.

Date :
  1. Date Completed 1995-02-21
  2. Date Revised 2019-11-01
Further Info :

Pubmed ID

7828459

DOI: Digital Object Identifier

10.1159/000457568

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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