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The effects of gonadotrophin-releasing hormone agonist on follicular development in patients with polycystic ovary syndrome in an in-vitro fertilization and embryo transfer programme.

Author: GersakK, Meden-VrtovecH, TomazevicT

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

In a study of 40 women with polycystic ovary syndrome undergoing in-vitro fertilization (IVF), pre-treatment with a gonadotropin-releasing hormone (GnRH) agonist before gonadotropin stimulation did not significantly affect ovarian response. While pre-treatment did temporarily correct hormonal imbalances, it did not change the number or size of follicles, the number of eggs retrieved or fertilized, or the number of embryos transferred. However, the average estrogen level was lower in the group that received pre-treatment.
Paper Details　
Original Abstract of the Article :
The aim of the study was to evaluate ovarian response to gonadotrophin stimulation, with and without premedication with gonadotrophin-releasing hormone (GnRH) agonist, in patients with polycystic ovary syndrome. In all, 40 women included in the in-vitro fertilization/embryo transfer programme were d...See full text at original site
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引用元：
https://doi.org/10.1093/oxfordjournals.humrep.a138758

データ提供：米国国立医学図書館（NLM）

A Journey Through the Desert of Polycystic Ovary Syndrome: Exploring Gonadotrophin-Releasing Hormone Agonist

This study delves into the complex world of polycystic ovary syndrome (PCOS), a hormonal disorder that affects women's reproductive health. It’s like exploring a vast desert landscape, where the delicate balance of hormones can be easily disrupted. The authors investigated the effects of gonadotrophin-releasing hormone (GnRH) agonist on follicular development in patients with PCOS undergoing in-vitro fertilization (IVF). They found that GnRH agonist premedication, while temporarily correcting endocrine abnormalities, did not significantly alter ovarian response to gonadotrophin stimulation or follicular development. It’s like trying to control the shifting sands of the desert—while you can make temporary adjustments, the underlying landscape remains largely unchanged.

The Complexities of PCOS and IVF Treatment

This study highlights the complexities of PCOS and its treatment. It's like navigating a desert terrain with hidden dangers and unexpected challenges. The study found that GnRH agonist premedication had a limited impact on follicular development, suggesting that other strategies might be needed to optimize IVF outcomes for women with PCOS.

The Ongoing Search for Effective Treatments

This study encourages continued research into effective treatments for PCOS and IVF. It's like a camel caravan searching for new oases of healing in the desert. The authors’ findings provide valuable insights into the limitations of GnRH agonist premedication and pave the way for further exploration of other potential treatment approaches.

Dr. Camel's Conclusion

This study reminds us that the desert of PCOS treatment is vast and complex. It's like a challenging journey with many obstacles, but with continued research and innovation, we can find new pathways to fertility and well-being.

Date :
  1. Date Completed 1995-02-24
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

7836506

DOI: Digital Object Identifier

10.1093/oxfordjournals.humrep.a138758

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Article Analysis
・Effective treatment of polycystic ovary syndrome
SNS
PICO Info
in preparation
Languages

English

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