Paper Details

  1. Home
  2. Paper Details

Effect of systemic adjuvant treatment on first sites of breast cancer relapse.

Author: CastiglioneM, CoatesA S, CollinsJ, GelberR D, GoldhirschA, HackingA, LindtnerJ, MariniG, PriceK N, RudenstamC M

Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A study of 2,830 women with node-positive breast cancer found that more intensive adjuvant therapy (multiple cycles of chemotherapy with or without tamoxifen) significantly reduced the incidence of local or regional and distant soft-tissue relapses at 10 years (36% to 18%). However, there was no effect on bone or visceral relapses. These findings suggest that current adjuvant treatments primarily benefit patients by reducing early-stage recurrence in specific areas, while having a smaller impact on later relapses in bone and internal organs. More intensive treatments currently being investigated may affect bone and visceral relapses and potentially lead to earlier and greater improvements in survival.
Paper Details　
Original Abstract of the Article :
Adjuvant systemic treatment for resectable breast cancer changes the natural history of the disease but provides only a small and delayed effect on survival. Evaluation of the types of first relapse avoided by available treatments may explain why effects on mortality are small and appear late during...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/s0140-6736(94)91221-1

データ提供：米国国立医学図書館（NLM）

Adjuvant Treatment for Breast Cancer: A Tale of Two Relapses

Breast cancer, a prevalent disease affecting millions worldwide, often requires adjuvant treatment to reduce the risk of relapse. This research examines the impact of adjuvant systemic treatment on different types of first relapse in patients with node-positive breast cancer. The study found that adjuvant treatment effectively reduced the incidence of local or regional and distant soft tissue relapses but had little impact on bone or visceral relapses.

Adjuvant Treatment: A Targeted Approach to Breast Cancer Relapse

This study sheds light on the nuances of adjuvant treatment in breast cancer, highlighting its effectiveness in preventing specific types of relapse. The findings suggest that more intensive treatments may be needed to address bone and visceral relapses, emphasizing the importance of individualized therapy based on individual patient characteristics and risk factors.

Navigating the Desert of Breast Cancer Treatment

Imagine a traveler navigating a vast and challenging desert, seeking a path to conquer breast cancer. Just as a traveler seeks a reliable source of water, individuals with breast cancer often search for effective treatments to prevent relapse and improve their chances of long-term survival. This research provides valuable insights into the impact of adjuvant treatment, highlighting its potential to prevent certain types of relapse while underscoring the need for further research to address other forms of recurrence.

Dr. Camel's Conclusion

This study underscores the importance of understanding the specific types of relapse that are most effectively addressed by adjuvant treatment for breast cancer. The findings highlight the need for ongoing research to develop more effective therapies to combat bone and visceral relapses, ultimately improving the long-term outcomes for breast cancer patients. As we continue to explore the desert of knowledge in search of better breast cancer treatments, we remain optimistic about the potential to improve patient lives and advance our fight against this debilitating disease.
Date :
  1. Date Completed 1994-03-04
  2. Date Revised 2019-06-11
Further Info :

Pubmed ID

7905550

DOI: Digital Object Identifier

10.1016/s0140-6736(94)91221-1

Related Literature

Article Analysis
・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.