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Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man.

Author: CurryS, LaderM, LogaS

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

Chlorpromazine accelerated its own metabolism by inducing liver microsomal oxidising enzymes in 17 patients, with phenobarbitone and orphenadrine further decreasing chlorpromazine concentrations.
Paper Details　
Original Abstract of the Article :
1 Two studies were carried out on acutely psychotic patients receiving chlorpromazine (100 mg) 8-hourly. 2 In the pilot study on five patients, plasma chlorpromazine concentrations fell over the course of 3 weeks of treatment and parallel changes were noted in the plasma half-life of antipyrine, sal...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/j.1365-2125.1975.tb01576.x

データ提供：米国国立医学図書館（NLM）

The Curious Case of Drug Interactions: Unveiling the Complexities of Pharmacokinetic Interactions

The field of [pharmacokinetics] delves into the intricate interplay between drugs and the body, exploring how drugs are absorbed, distributed, metabolized, and eliminated. This research, like a meticulous scientist studying the reactions within a desert ecosystem, investigates the interactions between orphenadrine, phenobarbitone, and chlorpromazine. The authors conducted two studies on patients receiving chlorpromazine, analyzing plasma concentrations and effects. Their findings highlight the potential for drug interactions to significantly alter drug efficacy and safety profiles.

Unveiling the Interplay of Drugs: A Complex Dance of Pharmacokinetic Interactions

This research, like a carefully choreographed dance involving various players, unveils the complex interplay of drugs within the body. The findings demonstrate that orphenadrine and phenobarbitone can significantly influence the pharmacokinetics of chlorpromazine, highlighting the importance of considering potential drug interactions in treatment planning.

Navigating the Desert of Drug Interactions: A Guide to Safe and Effective Treatment

This study, like a compass guiding travelers through a vast and potentially treacherous desert, emphasizes the importance of understanding drug interactions to ensure safe and effective treatment. The findings underscore the need for thorough medication reviews and a careful consideration of potential interactions to avoid adverse effects and optimize therapeutic outcomes.

Dr.Camel's Conclusion

This research, like a camel navigating a desert landscape dotted with various plants and animals, reveals the delicate balance within the realm of pharmacokinetics. The findings highlight the potential for drug interactions to significantly alter drug effects, reminding us to consider these interactions when prescribing medications and ensuring safe and effective treatment for our patients.

Date :
  1. Date Completed 1977-01-29
  2. Date Revised 2019-05-09
Further Info :

Pubmed ID

791320

DOI: Digital Object Identifier

10.1111/j.1365-2125.1975.tb01576.x

SNS
PICO Info
in preparation
Languages

English

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