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A clinical trial of bethanechol in patients with xerostomia after radiation therapy. A pilot study.

Author: BurchellJ L, EmertonS, EpsteinJ B, LeN D, SilvermanS

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Bethanechol, a cholinergic drug, was tested for its effectiveness in treating dry mouth (xerostomia) in patients who had undergone radiation therapy to the head and neck. Bethanechol significantly increased both resting and stimulated saliva production, suggesting its potential benefit in alleviating xerostomia.
Paper Details　
Original Abstract of the Article :
The effects of bethanechol in the treatment of dry mouth were assessed in patients with xerostomia after radiation therapy to the head and neck. Bethanechol possesses muscarinic and nicotinic-cholinergic activity that likely accounts for its mode of action. Bethanechol (25 mg, three times daily) was...See full text at original site
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引用元：
https://doi.org/10.1016/0030-4220(94)90320-4

データ提供：米国国立医学図書館（NLM）

Bethanechol: A Potential Oasis for Xerostomia

Xerostomia, or dry mouth, can be a debilitating condition, leaving individuals feeling uncomfortable and parched, like a traveler lost in a scorching desert. This study explores the potential of bethanechol, a medication that stimulates salivary gland activity, for treating xerostomia after radiation therapy.

Targeting Salivary Gland Activity

Bethanechol, like a desert spring revitalizing a parched landscape, targets the muscarinic and nicotinic-cholinergic receptors in salivary glands, stimulating the production of saliva.

Promising Results

The study found that bethanechol significantly increased both resting and stimulated saliva volumes, offering a potential solution for individuals struggling with dry mouth. The results suggest that bethanechol could be a valuable tool for improving the quality of life for patients experiencing xerostomia after radiation therapy.

Dr. Camel's Conclusion

This study provides promising evidence for the potential of bethanechol in treating xerostomia. By stimulating salivary gland activity, bethanechol can alleviate the discomfort and dryness associated with this condition, offering a potential oasis of relief for those struggling with xerostomia. As we navigate the vast and sometimes-parched desert of oral health, bethanechol stands as a potential source of moisture and rejuvenation, improving the overall well-being of patients.

Date :
  1. Date Completed 1994-09-20
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

7915026

DOI: Digital Object Identifier

10.1016/0030-4220(94)90320-4

Related Literature

Article Analysis
・Side Effects of bethanechol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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