Effects of tamoxifen on cardiovascular risk factors in postmenopausal women after 5 years of treatment.

Author: ChappellR J, FeyziJ M, LoveR R, NewcombP A, WiebeD A

Paper Details 
Original Abstract of the Article :
Adjuvant tamoxifen therapy for breast cancer has been given for a period of several years. Cardiovascular diseases increased in incidence rapidly in women older than 60 years. Favorable changes in cardiovascular risk factors have been seen with 2 years of tamoxifen therapy, and lower rates of myocar...See full text at original site
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引用元:
https://doi.org/10.1093/jnci/86.20.1534

データ提供:米国国立医学図書館(NLM)

Tamoxifen and Cardiovascular Health in Postmenopausal Women

This research dives deep into the effects of tamoxifen on the cardiovascular health of postmenopausal women. It's like a detective story, uncovering the long-term impact of tamoxifen on the heart, much like an archeologist carefully excavating a hidden tomb. The study used a meticulous approach, examining the cardiovascular risk factors in women after five years of treatment. They found that while tamoxifen had positive effects on these factors in the first two years, after five years the results became less clear. It’s important to note that this is a long-term study, a testament to the dedication of researchers, and the results emphasize the need for ongoing monitoring of cardiovascular health in women taking tamoxifen.

Long-Term Effects of Tamoxifen on Cardiovascular Risk Factors

The study revealed that while tamoxifen initially brought about favorable changes in cardiovascular risk factors, these benefits weren't consistently seen after five years. It’s like a sandcastle on the beach, beautiful and strong at first, but eventually susceptible to the forces of time and nature. It’s a reminder that even with positive initial results, long-term studies are crucial to understand the complete picture.

Implications for Postmenopausal Women

The research highlights the importance of regular cardiovascular checkups for postmenopausal women, especially those on tamoxifen therapy. It’s like navigating a desert, where the journey can be unpredictable. Just as you need a compass and a map to guide you, women on tamoxifen need regular monitoring to ensure their cardiovascular health remains on track.

Dr.Camel's Conclusion

This study underscores the need for long-term monitoring of cardiovascular health in postmenopausal women taking tamoxifen. It’s like a long caravan journey across the desert, requiring constant vigilance and adjustments to ensure a safe and successful outcome. The findings suggest that while tamoxifen offers initial benefits, its impact on cardiovascular health over the long term deserves careful observation.

Date :
  1. Date Completed 1994-10-28
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

7932809

DOI: Digital Object Identifier

10.1093/jnci/86.20.1534

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English

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