Androgen therapy in myelodysplastic syndromes with thrombocytopenia: a report on 20 cases.

Author: BautersF, CambierN, CaulierM T, FenauxP, SautièreD, WattelE

Paper Details 
Original Abstract of the Article :
Twenty patients with myelodysplastic syndromes (MDS) and (i) platelets < 50 x 10(9)/l and (ii) bone marrow blasts < or = 10% were treated with androgen therapy (fluoxymesterone at 1 mg/kg/d: seven patients; danazol at 600 mg/d: 13 patients) for at least 3 months. 11 of them (55%) had an increase in ...See full text at original site
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引用元:
https://doi.org/10.1111/j.1365-2141.1994.tb04895.x

データ提供:米国国立医学図書館(NLM)

Androgen Therapy: A Potential Solution for Myelodysplastic Syndromes

The world of [hematology] is constantly evolving, and researchers are always seeking new ways to treat complex blood disorders like [myelodysplastic syndromes (MDS)]. This study investigated the use of [androgen therapy] in patients with MDS and [thrombocytopenia]. The study involved [20 patients] and aimed to evaluate the efficacy and safety of androgen therapy in improving platelet counts and managing bleeding symptoms.

The authors observed that [androgen therapy] led to a significant increase in platelet counts in [55%] of the patients, with a notable reduction in bleeding symptoms in patients who initially experienced bleeding. The study also highlighted the potential benefits of androgen therapy in addressing [neutrophil counts and hemoglobin levels].

A Promising Treatment Option for MDS

This study provides evidence that androgen therapy may offer a valuable treatment option for patients with MDS, particularly those with low-risk MDS and severe thrombocytopenia. The findings suggest that androgen therapy can effectively improve platelet counts and manage bleeding symptoms, offering a potential alternative or complement to current treatments.

Considerations for Androgen Therapy

While this study shows promise, it's important to note that androgen therapy can have side effects. As with any medical treatment, careful consideration should be given to the potential benefits and risks, and treatment decisions should be made in consultation with a qualified healthcare professional.

Dr.Camel's Conclusion

Androgen therapy is like a oasis in the desert for patients with MDS. It offers a glimmer of hope, providing a potential solution to manage a challenging condition. However, like any oasis, it's crucial to approach it cautiously and with the guidance of experienced explorers (doctors) to ensure its beneficial effects are maximized.

Date :
  1. Date Completed 1994-12-07
  2. Date Revised 2019-07-05
Further Info :

Pubmed ID

7947249

DOI: Digital Object Identifier

10.1111/j.1365-2141.1994.tb04895.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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