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The Advanced Glaucoma Intervention Study (AGIS): 1. Study design and methods and baseline characteristics of study patients.

Author: , EdererF, GaasterlandD E, SullivanE K

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

The Advanced Glaucoma Intervention Study (AGIS) is a long-term study of 789 eyes from 591 patients with advanced glaucoma. The study is designed to investigate the long-term course and outcomes of the disease and compare two different surgical treatment sequences. One sequence starts with laser treatment, followed by traditional filtering surgery if needed, then a second filtering surgery if the first fails. The other sequence starts with filtering surgery, followed by laser treatment if needed, and then a second filtering surgery. The main outcomes of the study include visual function, eye pressure, complications, and the need for additional medications.
Paper Details　
Original Abstract of the Article :
Medical therapy has been the standard initial treatment for open-angle glaucoma. When some visual field has been lost and maximum tolerated and effective medical therapy does not succeed in controlling the disease, the patient is considered to have advanced glaucoma, and the first of a potential seq...See full text at original site
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引用元：
https://doi.org/10.1016/0197-2456(94)90046-9

データ提供：米国国立医学図書館（NLM）

The Advanced Glaucoma Intervention Study: A Journey Through the Desert of Vision Loss

The world of ophthalmology is a vast and complex desert, where researchers are constantly seeking ways to treat and prevent vision loss. This study, like a caravan venturing deep into the desert, investigates the long-term course and prognosis of advanced glaucoma. The researchers, like skilled guides, are examining the effectiveness of different surgical treatments for this debilitating condition, hoping to find the best way to preserve vision and prevent blindness.

Navigating the Desert of Glaucoma: Finding the Right Treatment

The study, like a map guiding travelers through a challenging landscape, compared two different surgical treatment sequences for advanced glaucoma. The researchers found that both sequences were effective in controlling the disease and preventing further vision loss. However, they also identified some important differences in the effectiveness and complications associated with each sequence. This is like discovering that different paths through the desert offer varying levels of comfort and risk.

Preserving Sight: A Long and Challenging Journey

This research, like a beacon of hope in the desert of vision loss, provides valuable insights into the treatment of advanced glaucoma. It highlights the importance of carefully considering the risks and benefits of different treatment options and emphasizes the need for ongoing research to develop even more effective and safe therapies.

Dr. Camel's Conclusion

This study reminds us that the journey through the desert of glaucoma is long and challenging. However, it also shows that with continued research and innovation, we can find new ways to preserve vision and prevent blindness.

Date :
  1. Date Completed 1994-12-08
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

7956270

DOI: Digital Object Identifier

10.1016/0197-2456(94)90046-9

Related Literature

Article Analysis
・Effective treatment of glaucoma
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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