Issues in combination antiretroviral therapy: a review.

Author: HammerS M, KesslerH A, SaagM S

Paper Details 
Original Abstract of the Article :
High viral burden and replication persist during all phases of human immunodeficiency virus (HIV) disease. Although monotherapy has yielded considerable benefits, these benefits are neither absolute nor durable. Combination therapy has multiple goals: to reduce viral replication and burden; to relie...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/7965649

データ提供:米国国立医学図書館(NLM)

Combination Antiretroviral Therapy for HIV

Human immunodeficiency virus (HIV) infection presents a significant challenge, requiring multifaceted treatment strategies to effectively suppress viral replication and manage disease progression. This review explores the evolution of antiretroviral therapy, from monotherapy to combination therapy, examining the rationale, regimens, and outcomes of different approaches. The authors emphasize the importance of combination therapy in achieving optimal viral suppression, reducing drug toxicity, and mitigating the development of drug resistance.

Combination Therapy for HIV

The review highlights the benefits of combination therapy, including a significant reduction in viral replication, a broader spectrum of activity against HIV, and the potential to delay or prevent the emergence of drug-resistant strains. The authors discuss various drug combinations and their effectiveness, emphasizing the importance of individualizing treatment based on the patient's specific circumstances and disease stage.

Implications for HIV Management

This review provides a comprehensive overview of the evolution and progress made in antiretroviral therapy for HIV. It highlights the critical role of combination therapy in managing HIV infection, emphasizing the need for ongoing research to develop even more effective and well-tolerated treatment regimens.

Dr.Camel's Conclusion

Imagine a vast desert landscape, where HIV infection is like a relentless sandstorm, threatening to engulf the body's immune system. Antiretroviral therapy, like a resourceful caravan, strives to combat this storm, with combination therapy being the most effective strategy for navigating this treacherous terrain. This review reminds us of the importance of continuous research and innovation in finding new and improved ways to manage HIV infection.

Date :
  1. Date Completed 1994-12-29
  2. Date Revised 2020-02-20
Further Info :

Pubmed ID

7965649

DOI: Digital Object Identifier

7965649

SNS
PICO Info
in preparation
Languages

English

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