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[Inhibitory effects of cyproheptadine on calmodulin activated Ca(2+)-ATPase activity of rabbit erythrocyte membranes].

Author: XinH B, ZhangB H

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effect of cyproheptadine on calmodulin-activated Ca(2+)-ATPase activity in rabbit erythrocyte membranes. Cyproheptadine inhibited CaM-activated Ca(2+)-ATPase activity, suggesting it may antagonize calmodulin.
Paper Details　
Original Abstract of the Article :
Membranes prepared from rabbit erythrocyte hemolyzed in isosmotic imidazole (151 mmol.L-1, pH 7.4) buffer showed an enhancement of calmodulin (CaM) activated Ca(2+)-ATPase activity compared with the membrane prepared in hypotonic imidazole (10 mmol.L-1, EGTA 1 mmol.L-1, pH 7.4) buffer. The Ca(2+)-AT...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8010076

データ提供：米国国立医学図書館（NLM）

Unlocking the Secrets of Calmodulin: Cyproheptadine's Role in Calcium Regulation

Calmodulin (CaM), a protein involved in regulating calcium, is crucial for cell function. It's like the gatekeeper of a bustling desert city, controlling the flow of essential resources. This study investigated the effects of cyproheptadine (Cyp), a drug commonly used for allergy relief, on the activity of CaM-activated Ca(2+)-ATPase, an enzyme that pumps calcium ions across cell membranes. The researchers found that Cyp inhibited the activity of CaM-activated Ca(2+)-ATPase, suggesting that Cyp acts as a CaM antagonist. This is like finding a traveler who has a special amulet that can block the gatekeeper from allowing certain resources into the city.

Calmodulin's Dance with Cyproheptadine: Understanding the Implications

The researchers suggest that Cyp's ability to antagonize CaM might explain its calcium-antagonistic and anti-myocardial injury properties. This means that Cyp might be able to prevent calcium from causing damage to the heart, like a shield protecting a city from invaders. This finding could lead to new therapeutic strategies for treating cardiovascular disorders.

A Desert Oasis of Knowledge: Implications for Health and Wellness

Understanding the interactions between CaM and Cyp could have implications for the development of new drugs that target specific pathways involved in calcium regulation. This is like uncovering hidden oases in the desert that provide a source of life-giving water. This knowledge could be used to develop new treatments for a variety of conditions, from allergies to heart disease.

Dr. Camel's Conclusion

This study provides intriguing insights into the complex world of calcium regulation. By understanding how Cyp interacts with CaM, we can gain valuable knowledge about potential therapeutic applications for this drug. This is like discovering a new route through the desert, leading to unexplored territories of knowledge and potential.

Date :
  1. Date Completed 1994-07-20
  2. Date Revised 2019-12-10
Further Info :

Pubmed ID

8010076

DOI: Digital Object Identifier

8010076

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Languages

Chinese

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