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Cardiorespiratory effects of induction and maintenance of anesthesia with ketamine-midazolam combination, with and without prior administration of butorphanol or oxymorphone.

Author: JacobsonJ D, McGrathC J, SmithE P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the cardiorespiratory effects of a ketamine-midazolam combination in dogs, with and without prior opioid administration. Ketamine-midazolam caused significant changes in cardiorespiratory variables, while opioid administration modulated these effects.
Paper Details　
Original Abstract of the Article :
Cardiorespiratory effects of an IV administered bolus of ketamine (7.5 mg/kg of body weight) and midazolam (0.375 mg/kg) followed by IV infusion of ketamine (200 micrograms/kg/min) and midazolam (10 micrograms/kg/min) for 60 minutes was determined in 6 dogs. Ketamine-midazolam combination was admini...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8017701

データ提供：米国国立医学図書館（NLM）

Ketamine-Midazolam Anesthesia: A Camel's Perspective on Cardiorespiratory Effects

Ketamine and midazolam are commonly used anesthetic agents, but their effects on the cardiorespiratory system can vary. This study investigates the cardiorespiratory effects of an intravenous (IV) administration of a ketamine-midazolam combination, both with and without prior opioid administration. The authors conducted a controlled study in dogs, carefully monitoring cardiorespiratory variables to understand the impact of different drug combinations. Their findings revealed significant changes in cardiorespiratory parameters, particularly in response to opioid administration.

Opioid Administration: A Potential Impact on Anesthesia

This study provides valuable insights into the potential impact of opioid administration on the cardiorespiratory effects of ketamine-midazolam anesthesia. The authors' findings highlight the importance of carefully considering the potential interactions between different anesthetic agents. This research can inform clinicians in their efforts to optimize anesthetic regimens and ensure patient safety during surgical procedures.

Anesthesia: A Carefully Choreographed Journey

Anesthesia is a complex process, involving careful consideration of drug combinations and individual patient factors. This study provides valuable insights into the potential impact of opioid administration on cardiorespiratory function during ketamine-midazolam anesthesia. It's crucial to consult with a healthcare professional to discuss the most suitable anesthetic approach for your individual needs.

Dr.Camel's Conclusion

The field of anesthesia is a fascinating journey, filled with intricate pathways and potential pitfalls. This study provides valuable insights into the cardiorespiratory effects of ketamine-midazolam anesthesia, particularly in the context of opioid administration. By understanding these interactions, clinicians can work toward optimizing anesthetic regimens and ensuring the safety and well-being of their patients.

Date :
  1. Date Completed 1994-07-22
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8017701

DOI: Digital Object Identifier

8017701

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Languages

English

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