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Mental decline in the elderly: pharmacotherapy (ergot alkaloids versus papaverine).

Author: RosenH J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.

Overview

Dihydrogenated ergot alkaloids (DEA) were significantly more effective than papaverine in improving symptoms associated with mental aging in older adults, particularly confusion, dizziness, unsociability, depressive mood, and mental alertness.
Paper Details　
Original Abstract of the Article :
This is the first double-blind study in outpatients to evaluate the effectiveness of dihydrogenated ergot alkaloids (DEA) (Hydergine) versus papaverine in the treatment of selected symptoms associated with mental aging. In addition, this is the first study comparing these two pharmacologic agents in...See full text at original site
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引用元：
https://doi.org/10.1111/j.1532-5415.1975.tb00164.x

データ提供：米国国立医学図書館（NLM）

Mental Decline in the Elderly: A Battle Against Time

Mental decline in the elderly, often associated with cognitive impairment and memory loss, can significantly impact quality of life. This research explores the use of pharmacotherapy, specifically dihydrogenated ergot alkaloids (DEA) and papaverine, to address symptoms associated with mental aging. The study, a double-blind trial, compares the effectiveness of DEA and papaverine in treating selected symptoms in relatively young geriatric patients.

DEA Emerges as a Potential Treatment Option

The results of the study show that DEA was significantly more effective than papaverine in improving a range of symptoms associated with mental aging, including confusion, dizziness, unsociability, depressive mood, and mental alertness. These findings suggest that DEA may be a promising treatment option for addressing cognitive decline in the elderly.

Potential for Improved Cognitive Function and Quality of Life

This research opens the door to potential treatments for cognitive decline in the elderly, potentially improving quality of life and maintaining independence. The study highlights the importance of considering pharmacotherapy as a potential treatment option, along with other interventions, for managing age-related cognitive decline.

Dr.Camel's Conclusion

Just as camels navigate the vast and unforgiving desert, researchers are constantly seeking ways to navigate the challenges of aging. This study provides a beacon of hope for those facing cognitive decline, highlighting the potential of DEA as a treatment option. This research is a testament to the ongoing efforts to improve the lives of the elderly and enhance their cognitive well-being.

Date :
  1. Date Completed 1975-05-27
  2. Date Revised 2019-07-09
Further Info :

Pubmed ID

803997

DOI: Digital Object Identifier

10.1111/j.1532-5415.1975.tb00164.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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