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Effect of flumazenil on recovery after midazolam and propofol sedation.

Author: GhouriA F, RuizM A, WhiteP F

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Flumazenil enhanced early recovery and picture recall after high-dose midazolam, but not low-dose midazolam. However, resedation after discharge was a concern with high-dose midazolam.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Flumazenil, a benzodiazepine antagonist, reverses midazolam-induced sedation and amnesia. We designed a double-blind study to evaluate the effects of flumazenil on patient outcome when flumazenil was used to reverse large or small doses of midazolam as part of standardized monitored anes...See full text at original site
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引用元：
https://doi.org/10.1097/00000542-199408000-00010

データ提供：米国国立医学図書館（NLM）

Flumazenil: A Benzodiazepine Antagonist for Enhanced Recovery After Sedation

The field of [anesthesia] is dedicated to ensuring patient safety and comfort during medical procedures. This research investigates the effectiveness of [flumazenil], a benzodiazepine antagonist, in reversing sedation induced by [midazolam and propofol]. The study employed a [double-blind] design to evaluate the impact of flumazenil on patient recovery after standardized monitored anesthesia care.

Flumazenil's Impact on Recovery: Enhanced Amnesia and Early Discharge

The research found that flumazenil significantly improved early recovery, including picture recall and time to discharge, in patients who received high doses of midazolam. However, the benefits were less pronounced in those who received low doses of midazolam. The study also noted that flumazenil improved cognitive function, as measured by the digit-symbol substitution test, in the first 60 minutes after the procedure.

Balancing Benefits and Risks: Resedation Considerations

While flumazenil can enhance recovery, the study highlights the potential risk of resedation after discharge, particularly in patients who received high doses of midazolam. This finding underscores the importance of careful monitoring and appropriate management strategies to minimize the risk of resedation. It's essential to consult with your healthcare provider to discuss any concerns about sedation and recovery.

Dr.Camel's Conclusion

This study is like a camel traversing a vast desert, where flumazenil acts as a guide, helping to navigate the path to recovery. The research highlights the benefits of flumazenil in accelerating recovery after sedation, particularly with high doses of midazolam. However, it also emphasizes the importance of considering the potential risk of resedation, especially in outpatient settings. Ultimately, the use of flumazenil should be carefully evaluated and managed to ensure a safe and comfortable recovery for patients.

Date :
  1. Date Completed 1994-09-08
  2. Date Revised 2019-06-28
Further Info :

Pubmed ID

8053582

DOI: Digital Object Identifier

10.1097/00000542-199408000-00010

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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