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Comparison of single-dose cefotetan and multidose cefoxitin as intravenous prophylaxis in elective, open biliary tract surgery: a multicentre, double-blind, randomized study.

Author: ConlyJ M, DagenaisM H, JolyJ R, LapointeR W, LewisR T, RoyA F, RoyP D, ScudamoreC H, SyrotuikJ, TurgeonP L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cefotetan was as effective as cefoxitin in preventing infections after biliary tract surgery, with a 1.8% infection rate for cefotetan. Both drugs had a similar rate of side effects, with 12.6% for cefotetan and 10.4% for cefoxitin.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To compare the safety, tolerance and prophylactic effectiveness of a single 2-g dose of cefotetan with a standard prophylactic regimen of cefoxitin in reducing the incidence of postoperative infections after elective, open biliary tract surgery. DESIGN: Multicentre, double-blind, randomi...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8055389

データ提供：米国国立医学図書館（NLM）

Cefotetan vs Cefoxitin: A Tale of Two Antibiotics in the Desert of Biliary Surgery

Biliary surgery, a complex and delicate procedure, is like navigating a treacherous desert filled with potential complications. Infection is a major concern, and this study focuses on the effectiveness of two antibiotics, cefotetan and cefoxitin, in preventing postoperative infections. The authors conducted a multicenter, double-blind, randomized study involving 111 patients undergoing elective, open biliary tract surgery. They compared the safety, tolerance, and prophylactic effectiveness of a single dose of cefotetan with a standard multi-dose regimen of cefoxitin. The study found that cefotetan was equally effective in reducing the incidence of postoperative infections compared to cefoxitin, with no significant differences in efficacy or adverse events. This research provides valuable insights into the comparative effectiveness of these antibiotics, offering surgeons a reliable and safe option for infection prophylaxis in biliary surgery.

Cefotetan: A Reliable Oasis in the Desert of Biliary Surgery

This study sheds light on the effectiveness of cefotetan as a single-dose prophylactic antibiotic in biliary surgery, demonstrating its comparable efficacy and safety to the standard multi-dose regimen of cefoxitin. The study's findings provide surgeons with a valuable option for infection prevention, potentially simplifying treatment protocols and improving patient outcomes.

Living with Biliary Conditions: Navigating the Desert with Confidence and Care

This research offers reassurance to patients undergoing biliary surgery, highlighting the effectiveness of cefotetan as a safe and reliable prophylactic antibiotic. It emphasizes the importance of choosing appropriate antibiotics for infection prevention in these complex procedures, minimizing the risk of complications and promoting a smoother recovery. Remember, navigating the desert of biliary conditions requires a careful and informed approach, working closely with your doctor to ensure a safe and successful journey.

Dr.Camel's Conclusion

This research compares the efficacy of two antibiotics, cefotetan and cefoxitin, in preventing postoperative infections after biliary surgery. The study found that cefotetan was equally effective as cefoxitin, offering surgeons a valuable alternative for infection prophylaxis.

Date :
  1. Date Completed 1994-09-13
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8055389

DOI: Digital Object Identifier

8055389

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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