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Ganciclovir transfer by human placenta and its effects on rat fetal cells.

Author: DeviB G, FrostoT A, HendersonG I, HuZ Q, PerezT B, SchenkerS, YangY

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Ganciclovir, a drug used to treat cytomegalovirus infection, crosses the placenta passively and without metabolism. While it is concentrated initially at the maternal placental surface, the transfer into the fetal compartment is slow. In vitro studies on rat fetal hepatocytes showed no significant toxicity of ganciclovir at high concentrations.
Paper Details　
Original Abstract of the Article :
Cytomegalovirus is a common cause of intrauterine infection. Ganciclovir is an accepted therapeutic agent for this infection, but is proscribed in pregnancy, except when there is a life-threatening maternal infection, because of its known teratogenic and embryotoxic effects in experimental animals. ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1097/00000441-199309000-00004

データ提供：米国国立医学図書館（NLM）

Ganciclovir's Journey: A Look at Placental Transfer and Fetal Effects

Cytomegalovirus (CMV) is a common viral infection that can cause serious complications during pregnancy. Ganciclovir, an antiviral drug, is used to treat CMV infection, but its use during pregnancy is controversial due to its potential teratogenic effects in animals. This study investigates the placental transfer of ganciclovir and its effects on cultured rat fetal hepatocytes.

Navigating the Placental Barrier: Ganciclovir's Journey to the Fetus

The study reveals that ganciclovir is actively transported across the maternal-facing placental membrane by a carrier-dependent system. However, its overall transfer across the placenta is passive. While the drug is initially concentrated at the maternal placental surface, it then crosses passively into the fetal compartment. The study found limited toxic effects of high ganciclovir concentrations on cultured rat fetal hepatocytes.

A Delicate Balance: Understanding the Risks and Benefits of Ganciclovir in Pregnancy

This research provides valuable insights into the pharmacokinetics of ganciclovir during pregnancy. It emphasizes the need for careful consideration of the potential risks and benefits when using this medication during gestation. Further research is crucial to fully understand the impact of ganciclovir on fetal development.

Dr. Camel's Conclusion

The desert of pregnancy is a delicate ecosystem, and navigating the use of medications can be challenging. This study sheds light on the journey of ganciclovir, reminding us that even seemingly simple processes can be complex and require careful consideration. It underscores the importance of research in understanding the interactions between drugs and the developing fetus.

Date :
  1. Date Completed 1994-04-14
  2. Date Revised 2019-07-17
Further Info :

Pubmed ID

8128975

DOI: Digital Object Identifier

10.1097/00000441-199309000-00004

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Languages

English

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