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[Principles of the pharmacokinetics and pharmacodynamics of calcium antagonists].

Author: RameisH

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Calcium antagonists (Ca-antagonists) are widely used for various circulatory diseases. Second-generation Ca-antagonists, like Amlodipine, have longer elimination half-lives, reducing the need for frequent dosing and minimizing side effects. Although they share similar biopharmaceutical and pharmacokinetic properties, there are quantitative differences in their acute pharmacodynamic effects.
Paper Details　
Original Abstract of the Article :
Today calcium antagonists (Ca-antagonists) are widely used agents in the management of various diseases of the circulatory system. More than 20 years ago the Ca-antagonists of the so-called 1st generation (Verapamil, Diltiazem, Nifedipine) were introduced for treatment of angina pectoris and later o...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8135031

データ提供：米国国立医学図書館（NLM）

Pharmacokinetics and Pharmacodynamics of Calcium Antagonists

Think of calcium antagonists (Ca-antagonists) like a refreshing oasis in a scorching desert, providing relief for a stressed cardiovascular system. This research explores the pharmacokinetic and pharmacodynamic properties of Ca-antagonists, highlighting their use in managing various cardiovascular diseases. The study discusses the development of first-generation Ca-antagonists (like Verapamil and Nifedipine) for treating angina pectoris and hypertension, followed by the emergence of second-generation Ca-antagonists (like Amlodipine) with improved pharmacokinetic profiles. The study emphasizes the need for careful consideration of hepatic and renal function when administering Ca-antagonists.

Calcium Antagonists: A Powerful Tool for Managing Cardiovascular Disease

This research provides valuable insights into the pharmacokinetic and pharmacodynamic properties of Ca-antagonists. The study highlights the evolution of these drugs, with second-generation Ca-antagonists offering improved therapeutic profiles. The findings emphasize the importance of tailoring treatment strategies based on individual patient characteristics, such as age, liver function, and kidney function.

Taking Care of Your Heart: A Healthy Lifestyle and Medical Guidance

Maintaining cardiovascular health is essential for overall well-being. This research highlights the importance of seeking medical advice and adhering to treatment recommendations when managing cardiovascular conditions. A healthy lifestyle, including a balanced diet, regular exercise, and stress management, is also crucial for preventing heart disease.

Dr. Camel's Conclusion

This research provides a comprehensive overview of the pharmacokinetic and pharmacodynamic properties of Ca-antagonists. The study sheds light on the evolution of these drugs, their mechanisms of action, and their impact on cardiovascular health. By understanding these properties, healthcare professionals can optimize treatment strategies for patients with cardiovascular disease and improve their quality of life.
Date :
  1. Date Completed 1994-04-21
  2. Date Revised 2007-11-15
Further Info :

Pubmed ID

8135031

DOI: Digital Object Identifier

8135031

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