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Phase III trial of initial chemotherapy in stage III or IV head and neck cancers: a study by the Gruppo di Studio sui Tumori della Testa e del Collo.

Author: CavanigliaG, FedeA, FilaG, JirilloA, MarchioriC, OrlandoA, PaccagnellaA, SileniV C, TomioL, ZoratP L

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Current standard treatments for advanced head and neck cancer (surgery with radiation or radiation alone) have not had good results. Several studies investigating the use of chemotherapy before surgery (induction chemotherapy) have not shown improved survival.
Paper Details　
Original Abstract of the Article :
The standard treatment for advanced (stage III and IV) head and neck squamous cell carcinoma (i.e., surgery with postoperative radiotherapy in operable patients and radiotherapy alone in inoperable patients) has had poor results. A series of randomized trials of induction chemotherapy have up to now...See full text at original site
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引用元：
https://doi.org/10.1093/jnci/86.4.265

データ提供：米国国立医学図書館（NLM）

The Quest for Effective Treatment for Head and Neck Cancers

This study delves into the challenging world of advanced head and neck cancers, specifically stage III and IV squamous cell carcinoma. The goal is to find more effective treatments for this aggressive form of cancer, much like searching for a hidden oasis in a vast and unforgiving desert. The research focuses on the role of initial chemotherapy as a potential treatment strategy.

Chemotherapy for Head and Neck Cancers: A Complex Landscape

The study reveals that while initial chemotherapy has been investigated as a potential treatment, it has not yet shown a significant improvement in survival rates for patients with advanced head and neck cancers. It's like navigating a desert with many false trails, making it difficult to find a clear path to success.

Continued Research for Improved Treatments

This research highlights the need for continued research and development of new and improved treatment strategies for head and neck cancers. It's a reminder that the journey to finding effective treatments is often long and challenging, much like a camel caravan crossing a vast and unforgiving desert.

Dr.Camel's Conclusion

This study underscores the ongoing challenge of treating advanced head and neck cancers. Further research is needed to find more effective treatment options, hopefully leading to a more hopeful outlook for patients facing this difficult diagnosis.

Date :
  1. Date Completed 1994-05-19
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

8158680

DOI: Digital Object Identifier

10.1093/jnci/86.4.265

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Article Analysis
・Effective treatment of head and neck cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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