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A two year trial of loxapine succinate in chronic psychotic patients.

Author: BrancheyM H, LeeJ H, SimpsonG M, VargaE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Loxapine succinate was effective and safe in treating chronic schizophrenia for at least two years. Improvements seen in the first six months were sustained over the following year and a half. Most side effects were mild to moderate and occurred mainly in the early months of treatment.
Paper Details　
Original Abstract of the Article :
Thirty-one chronic psychotic patients were treated with loxapine succinate, 20 for two years and eleven for one year, in order to evaluate its long-term efficacy and safety. Results presented here indicate that loxapine succinate is an effective treatment for chronic schizophrenia over a period of a...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/816626

データ提供：米国国立医学図書館（NLM）

Loxapine Succinate: A Long-Term Solution for Chronic Psychosis

This research evaluates the long-term efficacy and safety of loxapine succinate, an antipsychotic medication, in treating chronic psychotic patients. The study followed 31 patients for up to two years, assessing the drug's effectiveness in managing symptoms and its long-term side effect profile.

Loxapine Succinate: A Stable Oasis in the Desert of Psychosis

The study found that loxapine succinate was an effective treatment for chronic schizophrenia over a period of at least two years. Improvements in symptoms, observed during the initial six months of treatment, were sustained over the following 18 months. While side effects were more common during the early stages of treatment, they decreased over time. The most frequent side effects were mild to moderate extrapyramidal symptoms, which are movement disorders associated with some antipsychotic medications.

A Doctor's Perspective on Chronic Psychosis

As a physician, I understand the profound impact of chronic psychosis on individuals and their families. This study provides encouraging evidence for the long-term effectiveness and safety of loxapine succinate in managing chronic schizophrenia. The findings underscore the importance of individualized treatment plans that address the unique needs of each patient.

Dr.Camel's Conclusion

This research demonstrates the potential of loxapine succinate as a safe and effective long-term treatment for chronic schizophrenia. The study's findings provide valuable insights into the drug's efficacy and side effect profile, highlighting its potential role in managing this complex and challenging condition.
Date :
  1. Date Completed 1976-07-06
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

816626

DOI: Digital Object Identifier

816626

Related Literature

Article Analysis
・Side Effects of loxapine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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