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Safety, tolerability, and immunogenicity of an inactivated hepatitis A vaccine: effects of single and booster injections, and comparison to administration of immune globulin.

Author: AdlerR, AshurY, BrownL, KuterB, LewisJ A, MillerW, NalinD R, ShouvalD

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the safety, tolerability, and immunogenicity of an inactivated hepatitis A virus vaccine (iHAV) to immune globulin (IG) in adults. A single dose of the iHAV vaccine was found to be more effective and longer lasting than IG.
Paper Details　
Original Abstract of the Article :
Hepatitis A virus (HAV) infection in adults is often symptomatic and disabling. The present article summarizes our experience with phase 2 studies of an inactivated hepatitis A virus vaccine. Pre- and post-exposure prophylaxis with immune globulin (IG) is only effective for 4-6 months. We compared t...See full text at original site
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引用元：
https://doi.org/10.1016/s0168-8278(05)80375-7

データ提供：米国国立医学図書館（NLM）

A Safe and Effective Hepatitis A Vaccine

Hepatitis A, a viral infection that can cause significant liver damage, is like a hidden trap in the desert of human health. This study explores the safety, tolerability, and effectiveness of an inactivated hepatitis A virus vaccine. It's like finding a reliable camel caravan, offering protection against this dangerous disease.

A Powerful Weapon Against Hepatitis A

The study found that the inactivated hepatitis A vaccine was safe, well-tolerated, and highly effective in preventing hepatitis A infection. It's like a sturdy shield protecting us from the dangers of this disease. The study also compared the vaccine's effectiveness to immune globulin, a temporary measure that provides short-term protection. The vaccine proved superior, offering long-term protection against hepatitis A.

Navigating the Desert of Infectious Disease

This research underscores the importance of vaccination in preventing infectious diseases. It's like a map guiding us through the desert of infectious disease, helping us avoid the hidden traps and navigate safely. The study emphasizes the need for ongoing efforts to ensure widespread vaccination against hepatitis A, protecting individuals and communities from this potentially serious threat.

Dr.Camel's Conclusion

Hepatitis A, a dangerous foe in the desert of human health, can cause significant liver damage. This study, like a beacon of hope in the desert, demonstrates the effectiveness and safety of an inactivated hepatitis A vaccine. This vaccine, like a sturdy camel, offers us reliable protection against this disease, allowing us to navigate the desert of infectious disease with greater confidence.
Date :
  1. Date Completed 1994-06-16
  2. Date Revised 2019-08-17
Further Info :

Pubmed ID

8182270

DOI: Digital Object Identifier

10.1016/s0168-8278(05)80375-7

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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