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Effects of pravastatin in patients with serum total cholesterol levels from 5.2 to 7.8 mmol/liter (200 to 300 mg/dl) plus two additional atherosclerotic risk factors. The Pravastatin Multinational Study Group for Cardiac Risk Patients.

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Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pravastatin significantly lowered serum low-density lipoprotein cholesterol, total cholesterol and triglycerides, and raised serum high-density lipoprotein cholesterol in patients with hypercholesterolemia. It was associated with a significant reduction in the incidence of serious cardiovascular adverse events compared to placebo.
Paper Details　
Original Abstract of the Article :
This placebo-controlled, multinational study evaluated the use of pravastatin in 1,062 patients with hypercholesterolemia (serum total cholesterol concentrations of 5.2 to 7.8 mmol/liter [200 to 300 mg/dl]) and > or = 2 additional risk factors for atherosclerotic coronary artery disease. Efficacy an...See full text at original site
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引用元：
https://doi.org/10.1016/0002-9149(93)90858-a

データ提供：米国国立医学図書館（NLM）

Pravastatin: A Beneficial Effect on Cardiovascular Health

The heart is a vital organ, like the sun that sustains life in the desert. This study explores the potential of pravastatin, a statin medication, in reducing the risk of cardiovascular disease. The authors conducted a placebo-controlled trial to evaluate the efficacy and safety of pravastatin in patients with hypercholesterolemia and multiple risk factors for coronary artery disease.

Pravastatin: A Protective Shield Against Cardiovascular Disease

The study found that pravastatin effectively lowered serum lipid levels, including low-density lipoprotein cholesterol, total cholesterol, and triglycerides, while raising high-density lipoprotein cholesterol. Furthermore, the study revealed a significant reduction in the incidence of serious cardiovascular events, including myocardial infarction, unstable angina, and sudden cardiac death, in the pravastatin group compared to the placebo group.

Health Implications and Practical Applications

For individuals with high cholesterol and other risk factors for cardiovascular disease, pravastatin offers a potential benefit for protecting their heart health. However, it's crucial to consult with a healthcare professional to determine if pravastatin is the right treatment option. Remember, as a camel carefully selects its path to find water, we must carefully choose the right course of action to maintain our heart health.

Dr. Camel's Conclusion

This research underscores the importance of managing cholesterol levels to reduce the risk of cardiovascular disease. The study demonstrates that pravastatin can provide a beneficial effect on serum lipid levels and potentially reduce the incidence of serious cardiovascular events. It's a reminder that we must prioritize heart health, just as a camel relies on its endurance to navigate the harsh desert.

Date :
  1. Date Completed 1993-11-22
  2. Date Revised 2019-06-22
Further Info :

Pubmed ID

8213583

DOI: Digital Object Identifier

10.1016/0002-9149(93)90858-a

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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