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Rac-flurbiprofen is more ulcerogenic than its (S)-enantiomer.

Author: BigorniaA E, LevineB H, MurrayE D, WechterW J, YoungJ W

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The (R)-enantiomer of flurbiprofen, previously thought to be inactive, is non-ulcerogenic and can be used to reduce the gastrointestinal toxicity of the NSAID. In a study of mice, the (R)-enantiomer was shown to have no gastrointestinal toxicity, while the (S)-enantiomer and the racemate were ulcerogenic.
Paper Details　
Original Abstract of the Article :
The most common, and sometimes life-threatening, side-effects associated with the human use of the analgesic, nonsteroidal antiinflammatory drugs (NSAIDs) are gastrointestinal. These include gastritis, ulceration, and severe bleeding. The aryl propionic acid class of NSAIDs are among the most widely...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1002/chir.530050703

データ提供：米国国立医学図書館（NLM）

Rac-flurbiprofen: A Tale of Two Enantiomers

This research delves into the world of enantiomers, molecules that are mirror images of each other. It's like exploring two identical oases in the desert, each with its own unique properties. The study focuses on the effects of rac-flurbiprofen, a nonsteroidal anti-inflammatory drug (NSAID), on the stomach.

Enantiomers: Hidden Dangers in the Desert of Medication

The researchers found that the (R)-enantiomer of flurbiprofen, the mirror image of the active (S)-enantiomer, was surprisingly toxic to the stomach. It's like finding one oasis in the desert with life-giving water and another with a hidden well of poison. This finding highlights the importance of considering the effects of individual enantiomers when developing and using drugs.

Rac-flurbiprofen: A Cautionary Tale

The study suggests that using the racemic mixture of flurbiprofen, which contains both enantiomers, may increase the risk of stomach ulcers and other gastrointestinal problems. It's like traveling across the desert without knowing which oasis is safe. This research emphasizes the need for further investigation into the effects of enantiomers on different parts of the body.

Dr.Camel's Conclusion

This research sheds light on the hidden complexities of drug molecules, reminding us that even seemingly identical compounds can have dramatically different effects. It's a reminder that the journey through the desert of medication can be unpredictable, and we must proceed with caution and a deep understanding of the landscape.

Date :
  1. Date Completed 1994-01-05
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8240924

DOI: Digital Object Identifier

10.1002/chir.530050703

Related Literature

Article Analysis
・Side Effects of flurbiprofen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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