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Amplification of quinine cardiac effects by the resistance-reversing agent prochlorperazine in falciparum malaria.

Author: BatemanD N, EdsteinM, MothanaprakoonP, Na-NakornA, PlubhaN, WattG, WebsterH K

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

The use of reversing agents to overcome drug resistance could potentially amplify serious drug effects. In a study of 12 patients with falciparum malaria, prochlorperazine, a reversing agent, significantly prolonged the QTc interval after quinine administration. The prolongation was not observed with quinine alone, suggesting that the reversing agent amplified quinine-induced ECG changes.
Paper Details　
Original Abstract of the Article :
The use of reversing agents to overcome drug resistance is a potential new treatment strategy for both malaria and cancer. Laboratory studies have raised questions about the safety of this therapeutic approach, but data in humans are lacking. We therefore assessed the toxic potential of reversing ag...See full text at original site
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引用元：
https://doi.org/10.4269/ajtmh.1993.49.645

データ提供：米国国立医学図書館（NLM）

Quinine and Prochlorperazine: A Cautionary Tale of Drug Interactions

The emergence of drug resistance poses a significant challenge in treating various diseases. This study investigates the potential for drug interactions between quinine, a commonly used antimalarial drug, and prochlorperazine, a resistance-reversing agent. The research involved a randomized study with Thai patients receiving quinine for falciparum malaria, with some patients also receiving prochlorperazine. The authors found that prochlorperazine amplified the cardiac effects of quinine, leading to prolongation of the QTc interval, an electrocardiographic marker of cardiac toxicity. This study highlights the importance of careful monitoring for drug interactions and potential toxicities when using resistance-reversing agents.

Navigating the Desert of Drug Interactions: A Cautionary Tale

This study serves as a reminder that even seemingly safe medications can interact in unexpected ways. The finding that prochlorperazine amplified the cardiac effects of quinine underscores the importance of careful monitoring for drug interactions and potential toxicities, particularly when using resistance-reversing agents. This research highlights the need for further investigation into the safety and efficacy of resistance-reversing therapies.

The Desert of Drug Interactions: A Landscape of Complexity

Imagine a vast desert landscape where the shifting sands represent the complex interactions of medications. This is the analogy for drug interactions, where seemingly harmless combinations can lead to unforeseen consequences. This study underscores the importance of understanding the potential risks associated with drug interactions and the need for vigilance in monitoring patients receiving these therapies.

Dr. Camel's Conclusion

This study is like a warning sign in the desert of drug interactions, reminding us of the potential for unexpected consequences. It highlights the importance of careful monitoring and the need for further research to ensure the safe and effective use of resistance-reversing agents.

Date :
  1. Date Completed 1994-01-05
  2. Date Revised 2019-05-16
Further Info :

Pubmed ID

8250106

DOI: Digital Object Identifier

10.4269/ajtmh.1993.49.645

Related Literature

Article Analysis
・Effects of prochlorperazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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