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Effect of zolpidem on sleep in healthy subjects: a placebo-controlled trial with polysomnographic recordings.

Author: AttaliP, BloisR, CoquelinJ P, GaillardJ M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Zolpidem had minimal effects on polysomnographic variables in healthy young adults with normal sleep patterns. It exhibited a trend toward a hypnotic effect and slight transient inhibition of paradoxical sleep at the highest dose. There were no significant disruptions to sleep architecture, and adverse effects were limited to daytime drowsiness and one amnesic episode.
Paper Details　
Original Abstract of the Article :
The aims of this double-blind, placebo-controlled study, conducted in a group of healthy young adults with normal sleep patterns, were to ascertain the effect of various doses of zolpidem on polysomnographic variables and to determine whether zolpidem disrupts sleep architecture. Of the 15 subjects ...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/8269446

データ提供：米国国立医学図書館（NLM）

Zolpidem: A Sleep Aid With Minimal Sleep Architecture Disruption

Sleep is a fundamental aspect of our health and well-being. This research investigates the effects of zolpidem, a commonly prescribed sleep aid, on sleep architecture in healthy individuals. The authors conducted a double-blind, placebo-controlled study to assess the impact of zolpidem on sleep parameters. The findings suggest that zolpidem has a minimal disruptive effect on sleep architecture, offering insights into its potential benefits and drawbacks as a sleep aid. This study contributes to the growing body of knowledge surrounding the use of medications for sleep disorders, emphasizing the importance of understanding their effects on sleep patterns.

A Gentle Approach to Sleep: Minimizing Disruption

This research provides valuable insights into the effects of zolpidem on sleep architecture. It’s like navigating the vast desert of sleep patterns, seeking to find the ideal balance between restful sleep and minimal disruption. The study’s findings suggest that zolpidem can promote sleep without significantly altering the natural sleep cycle. This research offers a potential solution for individuals seeking a gentle approach to addressing sleep difficulties.

Sleep: A Vital Oasis in the Desert of Life

The research on zolpidem reminds us of the vital importance of sleep for our physical and mental health. It’s like an oasis in the vast desert of life, offering a space for rejuvenation and renewal. This study encourages continued exploration into the complexities of sleep and the development of safe and effective treatments for sleep disorders.

Dr. Camel's Conclusion

This research on zolpidem provides valuable insights into the delicate balance of sleep patterns and the potential impact of medications on our sleep cycles. It’s a reminder that the desert of sleep research is vast and ever-evolving. This study encourages continued exploration into the complexities of sleep, seeking to uncover the secrets of restful slumber and develop effective and safe solutions for those struggling with sleep disorders. The journey through the desert of sleep may be filled with unexpected challenges, but by pursuing knowledge and innovation, we can find oases of peace and rejuvenation.

Date :
  1. Date Completed 1994-02-03
  2. Date Revised 2018-11-30
Further Info :

Pubmed ID

8269446

DOI: Digital Object Identifier

8269446

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Article Analysis
・Effects of ulipristal・Effects of zolpidem
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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