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Captopril and hydrochlorothiazide (Capozide) combine to enhance the reduction in voluntary alcohol intake in rats.

Author: GruppL A, HardingS, RobertsonJ M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Capozide, a combination of captopril and hydrochlorothiazide, exhibited enhanced potency in suppressing voluntary alcohol intake in rats compared to the individual drugs.
Paper Details　
Original Abstract of the Article :
The effect of Capozide, the combination of captopril with a hydrochlorothiazide diuretic, on voluntary alcohol intake was assessed in two experiments. In experiment 1 naive rats who were maintained on ad libitum food and water were given daily 40-min access to a 6% (w/v) alcohol solution and water. ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1530-0277.1993.tb05647.x

データ提供：米国国立医学図書館（NLM）

Capozide: A Powerful Combination for Reducing Alcohol Intake

Excessive alcohol consumption is a significant public health concern, and researchers are constantly searching for effective treatments. This study investigates the potential of Capozide, a combination of captopril and hydrochlorothiazide, in reducing voluntary alcohol intake in rats. The researchers use a limited access procedure to assess the effects of Capozide on alcohol consumption, comparing it to the individual effects of captopril and hydrochlorothiazide.

Capozide: A More Effective Treatment Option for Alcohol Dependence

The study's findings demonstrate that Capozide exerts a supra-additive reduction in alcohol intake compared to the individual effects of its constituent drugs. This finding suggests that the combination of captopril and hydrochlorothiazide may be a more effective treatment option for reducing alcohol consumption than either drug alone. It's like combining the power of two camels to traverse a challenging desert, achieving a result greater than the sum of their individual efforts.

A New Hope for Alcohol Abuse Treatment

This study offers a promising new approach to treating alcohol dependence, highlighting the potential benefits of Capozide. The researchers suggest that further research is needed to explore the efficacy of Capozide in treating alcohol dependence in humans. This could lead to the development of new and effective treatment options for individuals struggling with alcohol abuse.

Dr.Camel's Conclusion

This study provides compelling evidence that Capozide, a combination of captopril and hydrochlorothiazide, may be a more effective treatment option for reducing alcohol intake compared to either drug alone. The researchers' findings suggest that Capozide exerts a supra-additive effect, offering a promising avenue for future research and clinical trials to evaluate its potential in treating alcohol dependence in humans.

Date :
  1. Date Completed 1994-02-08
  2. Date Revised 2019-08-25
Further Info :

Pubmed ID

8279680

DOI: Digital Object Identifier

10.1111/j.1530-0277.1993.tb05647.x

Related Literature

Article Analysis
・Effects of captopril and hydrochlorothiazide
SNS
PICO Info
in preparation
Languages

English

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