Paper Details

  1. Home
  2. Paper Details

Randomized comparison of the effects of tamoxifen, megestrol acetate, or tamoxifen plus megestrol acetate on treatment response and survival in patients with metastatic breast cancer.

Author: BurnsI, ByrneM, CoatesA, GebskiV, GillP G, LeviJ, SnyderR

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study investigated the effects of tamoxifen, megestrol acetate, and their combination in treating metastatic breast cancer.
Paper Details　
Original Abstract of the Article :
The antioestrogen tamoxifen and progestins act via different receptors and may therefore have complementary effects against human breast cancer. This possibility was tested in a randomized study which compared the effects of tamoxifen, standard-dose megestrol acetate, and these two agents in combina...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/8280654

データ提供：米国国立医学図書館（NLM）

Tamoxifen and Megestrol Acetate: A Combined Approach for Breast Cancer

Breast cancer, like a sandstorm in the desert, can be a formidable adversary. This study investigates the potential of combining two medications, tamoxifen and megestrol acetate, to treat metastatic breast cancer, a type of breast cancer that has spread to other parts of the body. The researchers, like explorers seeking a cure, conducted a randomized trial comparing the effects of tamoxifen, megestrol acetate, and a combination of both on treatment response and survival in patients with metastatic breast cancer.

A Combined Approach: A Possible Oasis

The study found that a combination of tamoxifen and megestrol acetate did not significantly improve treatment response or survival compared to either medication alone. While both medications have been shown to be effective in treating breast cancer, the combination did not provide a synergistic benefit. This finding suggests that a combined approach may not be necessary for all patients with metastatic breast cancer.

Navigating the Desert of Cancer Treatment

This study is like a guidepost in the desert of cancer treatment, providing valuable insights into the effectiveness of different treatment approaches. While the combination of tamoxifen and megestrol acetate did not show a significant advantage, the study emphasizes the importance of personalized care and careful consideration of treatment options for each individual patient.

Dr.Camel's Conclusion

This research, like a camel traversing the vast desert of cancer treatment, explores the potential of combining different medications to improve outcomes for patients with metastatic breast cancer. While the study found that a combined approach did not provide a significant advantage, it highlights the importance of personalized care and careful consideration of treatment options for each individual patient.
Date :
  1. Date Completed 1994-02-17
  2. Date Revised 2020-02-03
Further Info :

Pubmed ID

8280654

DOI: Digital Object Identifier

S0923-7534(19)64949-5

Related Literature

Article Analysis
・Effects of tamoxifen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.