Paper Details

  1. Home
  2. Paper Details

The anxiolytic effects of intravenous sedation using midazolam alone or in multiple drug techniques.

Author: BeirneO R, FisetL, MilgromP, WeinsteinP

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

In a study of 207 young adults undergoing surgery, the combination of fentanyl and midazolam or fentanyl, midazolam, and methohexital was more effective than placebo in reducing anxiety.
Paper Details　
Original Abstract of the Article :
This study examines four drug combinations (midazolam, midazolam-midazolam, fentanyl-midazolam, and fentanyl-midazolam-methohexital) in a placebo-controlled double-blind clinical trial of intravenous sedation. It tests the hypothesis that there is no difference between the anxiolytic effect of the f...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0278-2391(94)90285-2

データ提供：米国国立医学図書館（NLM）

The Anxiolytic Effects of Sedation: A Desert of Calm

Dental procedures can be a source of anxiety for many individuals. Imagine facing a daunting dental procedure, feeling like you're traversing a vast, daunting desert. This study examines the anxiolytic effects of various intravenous sedation combinations, seeking to find the ideal combination for calming patients before surgery. The researchers wanted to find the perfect oasis of calm, easing the anxiety associated with these procedures.

Finding the Oasis of Calm

The researchers compared four drug combinations: midazolam, midazolam-midazolam, fentanyl-midazolam, and fentanyl-midazolam-methohexital. They discovered that the fentanyl-midazolam group showed the most promising results. This group was significantly more likely to experience successful anxiolysis compared to the placebo group. The researchers concluded that this combination was the most effective in creating a tranquil desert of calm for the patients.

Navigating the Desert of Dental Anxiety

The study highlights the potential benefits of using sedation to manage dental anxiety. By finding the right combination of medications, we can help patients navigate the desert of dental fear with greater ease and comfort. However, it is important to consult with a qualified healthcare professional to determine the appropriate sedation approach for individual needs.

Dr.Camel's Conclusion

This study offers a valuable roadmap for navigating the desert of dental anxiety. By understanding the specific anxiolytic effects of different sedation combinations, we can find the perfect oasis of calm for our patients, easing the anxieties associated with dental procedures. As researchers continue to explore these options, we're closer to finding a solution that allows everyone to face their dental challenges with greater peace of mind.

Date :
  1. Date Completed 1994-03-16
  2. Date Revised 2019-08-14
Further Info :

Pubmed ID

8308619

DOI: Digital Object Identifier

10.1016/0278-2391(94)90285-2

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.