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Ethacrynic acid: outflow effects and toxicity in human trabecular meshwork in perfusion organ culture.

Author: JohnsonD H, TschumperR C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Ethacrynic acid is effective in temporarily lowering intraocular pressure in the human eye, but a low therapeutic index may limit its clinical usefulness.
Paper Details　
Original Abstract of the Article :
The effect of ethacrynic acid, a potential outflow agent for the treatment of glaucoma, was studied in a series of 25 pairs of human eyes in perfusion organ culture. Concentrations varied from 0.01 mM to 2.4 mM and were used in single or repetitive doses. Intraocular pressure was continuously record...See full text at original site
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引用元：
https://doi.org/10.3109/02713689309024620

データ提供：米国国立医学図書館（NLM）

Ethacrynic Acid: A Promising Glaucoma Treatment?

This research examines the potential of [ethacrynic acid] as a treatment for [glaucoma], a condition that affects [intraocular pressure]. The study utilizes [perfusion organ culture] to investigate the effects of [ethacrynic acid] on the [human trabecular meshwork], a key structure involved in [aqueous humor outflow].

Ethacrynic Acid: A Double-edged Sword

The study reveals that [ethacrynic acid] can effectively lower [intraocular pressure] in [human eyes] but also highlights its potential for [toxicity]. While [ethacrynic acid] can temporarily increase [facility of outflow], it can also cause [dose-dependent damage] to the [trabecular meshwork] cells, potentially limiting its long-term usefulness.

Eye Health: Protecting Our Vision

This study underscores the importance of careful [drug selection] and [dosing] when treating [glaucoma]. It's essential to work closely with an [ophthalmologist] to determine the best course of treatment based on individual needs and risk factors.

Dr. Camel's Conclusion

This research provides valuable insights into the potential of [ethacrynic acid] as a treatment for [glaucoma]. While it shows promise in lowering [intraocular pressure], its potential for [toxicity] necessitates further research and careful consideration. It's like a camel navigating a desert, choosing the right path to avoid the dangers of quicksand while seeking the oasis of improved eye health.

Date :
  1. Date Completed 1993-09-07
  2. Date Revised 2019-08-30
Further Info :

Pubmed ID

8344063

DOI: Digital Object Identifier

10.3109/02713689309024620

Related Literature

Article Analysis
・Effects of ethacrynic acid
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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