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Original Abstract of the Article :
Prokinetic agents are currently being investigated as potential therapies for motility disorders of the lower gastrointestinal tract. Cholinergic agonists such as bethanechol are known to improve postoperative ileus but are limited because of side effects. Dopamine antagonists such as domperidone ap...See full text at original site
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引用元:
https://doi.org/10.1007/BF02238599
データ提供:米国国立医学図書館(NLM)
Moving Things Along: Prokinetic Agents for Lower Gastrointestinal Motility Disorders
Our digestive system is like a complex network of pipes, and when things get backed up, it can cause discomfort and pain. Prokinetic agents are medications that help to stimulate muscle contractions in the digestive tract, like a little push to get things moving again. Researchers reviewed the use of prokinetic agents in the treatment of motility disorders of the lower gastrointestinal tract. They explored the efficacy of various agents, including cholinergic agonists, dopamine antagonists, opioid antagonists, motilin agonists, and others. Some of these agents, like bethanechol and domperidone, work primarily in the upper digestive tract. Others, like naloxone, erythromycin, and cisapride, show promise for lower gastrointestinal motility disorders. They found that cisapride, a motilin agonist, appears to be particularly effective in patients with postoperative ileus and chronic constipation.
Cisapride: A Potential Solution for Lower Gastrointestinal Motility Disorders
The researchers identified cisapride as a promising prokinetic agent for lower gastrointestinal motility disorders. It seems to be particularly effective in treating postoperative ileus and chronic constipation, which is like clearing blockages in the pipes. They found that cisapride was associated with an increased return of bowel function in patients with postoperative ileus and increased stool frequency and decreased laxative abuse in patients with chronic constipation.
Finding Relief: What this Research Means for You
This research suggests that prokinetic agents, particularly cisapride, may be helpful in treating lower gastrointestinal motility disorders. If you're struggling with constipation or other motility issues, talk to your doctor to see if a prokinetic agent might be right for you. It's like consulting a plumber who can help you troubleshoot the problem and find the best solution.
Dr.Camel's Conclusion
This review delves into the intricate world of gastrointestinal motility and highlights the potential of prokinetic agents to alleviate digestive woes. Like a skillful desert navigator guiding a caravan through challenging terrain, prokinetic agents can help to navigate the complex pathways of our digestive system, ensuring a smooth and efficient journey.
Date :
- Date Completed 1993-09-10
- Date Revised 2019-07-21
Further Info :
Related Literature
English
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