Paper Details

  1. Home
  2. Paper Details

PGH synthase isoenzyme selectivity: the potential for safer nonsteroidal antiinflammatory drugs.

Author: DeWittD L, MeadeE A, SmithW L

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Two isozymes of prostaglandin endoperoxide (PGH) synthase, PGHS-1 and PGHS-2, have been identified. PGHS-1 is constitutively expressed and involved in housekeeping functions, while PGHS-2 is expressed in inflamed tissues. NSAIDs can preferentially inhibit either isozyme, offering a potential approach to developing safer and more effective anti-inflammatory drugs. Nabumetone is the only NSAID currently known to preferentially inhibit PGHS-2.
Paper Details　
Original Abstract of the Article :
With the recent cloning of a second gene coding for the prostaglandin endoperoxide (PGH) synthase (cyclooxygenase), it has become obvious that mammalian cells contain two related, but unique, isozymes of PGH synthase. Both of these isozymes catalyze the conversion of arachidonic acid to PGH2, leadin...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0002-9343(93)90396-7

データ提供：米国国立医学図書館（NLM）

PGH Synthase Isoenzyme Selectivity and Safer NSAIDs

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used to relieve pain and inflammation, but they can also cause side effects. This study investigates the potential for developing safer NSAIDs by targeting specific isoforms of the enzyme PGH synthase (cyclooxygenase). Think of it as exploring a desert landscape with different species of plants – some are harmless while others contain toxic substances. The researchers explored the possibility of selectively targeting specific isoforms of PGH synthase to develop safer NSAIDs.

Targeting PGH Synthase Isozymes for Safer NSAIDs

The study found that different NSAIDs can selectively inhibit different isoforms of PGH synthase. This suggests that developing drugs that specifically target the inflammatory isoform (PGHS-2) while sparing the protective isoform (PGHS-1) could lead to safer and more effective NSAIDs. It's like discovering a poison that only affects certain plants in the desert – allowing for targeted control of harmful species without harming beneficial ones.

Hope for Safer Pain Relief

This research offers hope for developing safer and more effective NSAIDs that can alleviate pain and inflammation without the risks of gastrointestinal or renal side effects. It's like finding a new weapon in the desert that can target specific enemies without harming the surrounding environment.

Dr. Camel's Conclusion

This study is a testament to the ongoing pursuit of safer and more effective medications. It encourages continued research into the mechanisms of action of NSAIDs, ultimately paving the way for a more targeted and personalized approach to pain management.

Date :
  1. Date Completed 1993-09-23
  2. Date Revised 2019-06-27
Further Info :

Pubmed ID

8357002

DOI: Digital Object Identifier

10.1016/0002-9343(93)90396-7

Related Literature

Article Analysis
・Side Effects of nabumetone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.