Olsalazine in maintenance of clinical remission in patients with ulcerative colitis.

Author: CumingL, JaskiewiczK, O'KeefeE A, WrightJ P

Paper Details 
Original Abstract of the Article :
Frequent minor side effects are associated with sulfasalazine. The realization that it is the 5-aminosalicylic acid moiety that is the active component of sulfasalazine and that the side effects are probably due to the sulfapyridine has prompted the search for a similar but safer compound. Olsalazin...See full text at original site
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引用元:
https://doi.org/10.1007/BF01296107

データ提供:米国国立医学図書館(NLM)

Olsalazine for Maintaining Remission in Ulcerative Colitis

The treatment of ulcerative colitis, a chronic inflammatory bowel disease, often involves medications with potential side effects. This research investigates the efficacy and safety of olsalazine, a drug designed to avoid the side effects associated with sulfasalazine, in maintaining remission in patients with ulcerative colitis. The researchers conducted a double-blind placebo-controlled trial, a rigorous study design that minimizes bias and provides reliable results.

Olsalazine Offers Longer Remission

The study found that olsalazine significantly prolonged the time to relapse compared to placebo. While olsalazine did have some side effects, mainly diarrhea, it was generally well-tolerated, particularly for patients who did not experience diarrhea. The study also found that the incidence of minor side effects was similar in both the olsalazine and placebo groups, and no major or dangerous side effects were reported.

Managing Ulcerative Colitis: A Safer Option

This research provides evidence supporting the use of olsalazine as a safe and effective treatment option for maintaining remission in patients with ulcerative colitis. The findings suggest that olsalazine may be a suitable alternative for patients who experience side effects from sulfasalazine. It's like finding a cooler, more refreshing oasis in the desert of ulcerative colitis treatment options.

Dr.Camel's Conclusion

This study, like a refreshing wellspring in the desert, offers hope for patients with ulcerative colitis. The research suggests that olsalazine may be a safer and more effective option for maintaining remission, providing relief from the debilitating symptoms of this chronic condition. Remember, even in the challenging desert of chronic illness, there are often oases of hope and effective treatment options.

Date :
  1. Date Completed 1993-11-10
  2. Date Revised 2020-03-04
Further Info :

Pubmed ID

8404404

DOI: Digital Object Identifier

10.1007/BF01296107

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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