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Octreotide versus loperamide in the treatment of fluorouracil-induced diarrhea: a randomized trial.

Author: CascinuS, CatalanoG, FedeliA, FedeliS L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Octreotide and loperamide are drugs that are used to treat diarrhea. This study found that octreotide was more effective than loperamide at treating diarrhea caused by fluorouracil, a chemotherapy drug.
Paper Details　
Original Abstract of the Article :
Diarrhea is a prominent feature of fluorouracil (5FU) gastrointestinal toxicity, especially when 5FU is combined with leucovorin (LV) or interferon (IFN). No treatment for this condition has been well defined, although drugs, such as diphenoxylate or loperamide, generally are used. The efficacy of o...See full text at original site
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引用元：
https://doi.org/10.1200/JCO.1993.11.1.148

データ提供：米国国立医学図書館（NLM）

Octreotide vs Loperamide: A Race Through the Desert of Diarrhea

Diarrhea can be a debilitating side effect of certain cancer treatments, like fluorouracil (5FU). This study examines the effectiveness of two different medications, octreotide and loperamide, in managing 5FU-induced diarrhea. The authors conducted a randomized trial to compare the effectiveness of these drugs in reducing the severity of diarrhea in patients undergoing 5FU therapy.

A Head-to-Head Comparison

The results of the study reveal that octreotide was more effective than loperamide in treating 5FU-induced diarrhea. This finding suggests that octreotide may be a more appropriate treatment option for patients experiencing severe diarrhea related to 5FU therapy.

Managing Diarrhea: A Desert of Solutions

This study provides valuable information for healthcare professionals seeking to effectively manage 5FU-induced diarrhea. Octreotide, like a sturdy camel traversing a challenging desert terrain, offers a promising solution for mitigating the discomfort and disruption caused by this common side effect.

Dr. Camel's Conclusion

Octreotide emerges as the victor in this race against 5FU-induced diarrhea. This study highlights the importance of exploring effective treatment options to help cancer patients navigate the challenging side effects of their therapies.

Date :
  1. Date Completed 1993-02-02
  2. Date Revised 2017-02-10
Further Info :

Pubmed ID

8418225

DOI: Digital Object Identifier

10.1200/JCO.1993.11.1.148

Related Literature

Article Analysis
・Side Effects of diphenoxylate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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