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Bactericidal effect of beta-lactams and amikacin alone or in association against Klebsiella pneumoniae producing extended spectrum beta-lactamase.

Author: BerrouaneY, CourcolR J, GoffartM, GourdeB, Roussel-DelvallezM, SirotD, WalletF

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cefotaxime plus co-amoxiclav, a combination of antibiotics, was as effective as imipenem in treating infections caused by extended spectrum beta-lactamase-producing Klebsiella pneumoniae.
Paper Details　
Original Abstract of the Article :
Ten extended spectrum beta-lactamases producing strains of Klebsiella pneumoniae characterized by analytical isoelectric focusing and studied for their susceptibility to beta-lactam antibiotics, either alone or in combination with a beta-lactamase inhibitor (clavulanic acid and sulbactam) and in ass...See full text at original site
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引用元：
https://doi.org/10.1093/jac/36.1.241

データ提供：米国国立医学図書館（NLM）

Fighting Beta-Lactamase Producing Klebsiella Pneumoniae: A Battle in the Desert of Antibiotic Resistance

This research delves into the challenging world of antibiotic resistance, focusing on the emergence of extended-spectrum beta-lactamases (ESBLs) producing *Klebsiella pneumoniae*. The study examines the bactericidal effects of various antibiotics, including beta-lactams and amikacin, against ESBL-producing *K. pneumoniae*. The researchers found that combinations of cefotaxime plus co-amoxiclav with or without amikacin exhibited strong bactericidal activity, offering potential therapeutic options for infections caused by ESBL-producing *K. pneumoniae*.

Navigating the Shifting Sands of Antibiotic Resistance

This research highlights the critical challenge of antibiotic resistance, focusing on the emergence of ESBLs producing *K. pneumoniae*. The study's findings provide valuable insights into the potential therapeutic options for infections caused by these resistant bacteria, offering hope in the ongoing battle against antibiotic resistance. This journey through the desert of antibiotic resistance requires a multidisciplinary approach, combining clinical expertise, research, and public health initiatives to address this pressing global health concern.

The Importance of Combating Antibiotic Resistance

This research underscores the importance of combating antibiotic resistance, a growing threat to global health. The study's findings highlight the need for continuous research and development of new antibiotics and therapeutic strategies to effectively address infections caused by resistant bacteria. This journey through the desert of antibiotic resistance requires a collaborative effort between scientists, clinicians, and public health officials to protect human health and prevent the spread of resistant infections.

Dr. Camel's Conclusion

This research highlights the critical challenge of antibiotic resistance, focusing on the emergence of ESBLs producing *K. pneumoniae*. The study's findings provide valuable insights into potential therapeutic options for infections caused by these resistant bacteria, offering hope in the ongoing battle against antibiotic resistance. This journey through the desert of antibiotic resistance requires a multidisciplinary approach, combining clinical expertise, research, and public health initiatives to address this pressing global health concern.
Date :
  1. Date Completed 1996-02-06
  2. Date Revised 2019-05-12
Further Info :

Pubmed ID

8537274

DOI: Digital Object Identifier

10.1093/jac/36.1.241

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Languages

English

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