Alternate antiestrogens and approaches to the prevention of breast cancer.

Author: JordanV C

Paper Details 
Original Abstract of the Article :
The biological rationale and extensive clinical experience with the breast cancer drug tamoxifen make it the agent of choice for testing as a breast cancer preventive. However, concerns (Jordan and Morrow, Eur J Cancer, in press) about development of endometrial cancer in patients and liver tumors i...See full text at original site
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引用元:
https://doi.org/10.1002/jcb.240590808

データ提供:米国国立医学図書館(NLM)

Preventing Breast Cancer: A Quest for New Antiestrogens

The quest for effective breast cancer prevention strategies is a long and winding journey, like a camel traversing a vast and unforgiving desert. This research focuses on the role of antiestrogens, medications that block the effects of estrogen, in preventing breast cancer. The researchers seek to identify new antiestrogens, like searching for hidden oases in the desert, offering a promise of protection against this dreaded disease.

While tamoxifen, a well-established antiestrogen, has proven effective in treating breast cancer, it also comes with potential side effects. This has driven the search for alternative antiestrogens, less toxic but equally effective. Two triphenylethylenes, toremifene and droloxifene, have shown promise in clinical trials for advanced breast cancer, offering a potential alternative to tamoxifen. The researchers also explore the possibility of using raloxifene, a drug currently being tested for osteoporosis, as a potential breast cancer preventive agent. This is like discovering that a particular type of oasis not only provides water but also possesses unique properties that can protect against disease.

A Promising Future for Breast Cancer Prevention: Discovering New Oases of Hope

The research points towards a promising future for breast cancer prevention. The identification of new antiestrogens and the exploration of existing drugs with potential preventive properties offer a beacon of hope for women seeking to reduce their risk of developing this disease. This is like discovering a new map that reveals the location of multiple oases, each offering a unique pathway to protection and well-being.

Dr. Camel's Conclusion

The research highlights the importance of continuing the search for new and effective breast cancer prevention strategies. The identification of alternative antiestrogens and the exploration of existing drugs with potential preventive properties offer a pathway towards a future where breast cancer is less common and more treatable. It also emphasizes the importance of personalized medicine, choosing the right treatment for each individual based on their unique needs and risks.

Date :
  1. Date Completed 1996-02-06
  2. Date Revised 2022-03-09
Further Info :

Pubmed ID

8538210

DOI: Digital Object Identifier

10.1002/jcb.240590808

Related Literature

SNS
PICO Info
in preparation
Languages

English

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